General
Preferred name
RILPIVIRINE
Synonyms
DB08864 ()
TMC278 ()
R278474 ()
Rilpivirine (hydrochloride) ()
RILPIVIRINE HYDROCHLORIDE ()
TMC-278 (hydrochloride) ()
TMC278 (hydrochloride) ()
TMC 278 (hydrochloride) ()
R278474, TMC278, DB08864 ()
Edurant ()
R 278474 ()
TMC-278 ()
R-278474 ()
TMC278 HYDROCHLORIDE ()
Rilpivirine (as hydrochloride) ()
Rilpivirine hcl ()
Rilpivirine ()
Rilpivirine-d6 (hydrochloride) ()
P&D ID
PD004299
CAS
500287-72-9
700361-47-3
Tags
available
drug
Approved by
PMDA
FDA
First approval
2011
Drug Status
approved
Drug indication
Human immunodeficiency virus infection
Pain
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Rilpivirine is an oral non-nucleoside reverse transcriptase inhibitor (NNRTI) HIV medication. (GtoPdb)
Cell lines
1
Organisms
3
Compound Sets
18
AdooQ Bioactive Compound Library
A11542
Cayman Chemical Bioactives
21559
26520
ChEMBL Approved Drugs
CHEMBL175691
CHEMBL1628504
ChEMBL Drugs
CHEMBL175691
CHEMBL1628504
Drug Repurposing Hub
DrugBank
DB08864
DrugBank Approved Drugs
DB08864
DrugCentral
4174
DrugCentral Approved Drugs
4174
DrugMAP
DMJ0QOW
DrugMAP Approved Drugs
DMJ0QOW
EU-OPENSCREEN Bioactive Compound Library
EOS100150
Guide to Pharmacology
11387
MedChem Express Bioactive Compound Library
HY-10574
HY-10574A
NCATS Inxight Approved Drugs
FI96A8X663
ReFrame library
Selleckchem Bioactive Compound Library
rilpivirine
rilpivirine-hydrochloride
TargetMol Bioactive Compound Library
T2330
External IDs
57
Properties
(calculated by RDKit )
Molecular Weight
366.16
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
4.99
TPSA
97.42
Fraction CSP3
0.09
Chiral centers
0.0
Largest ring
6.0
QED
0.62
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Pathway
Microbiology&virology
Anti-infection
Metabolic Enzyme/Protease
Target
Reverse Transcriptase
NR1I2, SCN10A
HIV
MMP
SARS-CoV
Indication
human immunodeficiency virus (HIV-1)
MOA
non-nucleoside reverse transcriptase inhibitor
Source data