General
Preferred name
TNP-470
Synonyms
O-Chloroacetylcarbamoylfumagillol ()
AGM-1470 ()
NSC-642492 ()
P&D ID
PD004263
CAS
129298-91-5
Tags
available
covalent binder
drug candidate
natural product
Drug indication
Solid tumour/cancer
Drug Status
investigational
Max Phase
Phase 2
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
TNP-470 is an analog of fumagillin, an antimicrobial agent isolated from the fungus Aspergillus fumigatus. TNP-470 was shown to inhibit angiogenesis, and irreversibly suppress methionine aminopeptidase-2 (MetAP2).
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
7
Organisms
0
Compound Sets
11
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
CovalentInDB
Drug Repurposing Hub
DrugBank
DrugMAP
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
26
Molecular Weight
401.16
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
0
cLogP
2.55
TPSA
89.69
Fraction CSP3
0.79
Chiral centers
6.0
Largest ring
6.0
QED
0.42
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Member status
virtual
MOA
Methionine Aminopeptidase-2 (MetAP2) Inhibitors
Angiogenesis Inhibitors
methionine aminopeptidase inhibitor
Target
METAP2
Aminopeptidase
Pathway
Metabolic Enzyme/Protease
Source data
