General
Preferred name
FG-2216
Synonyms
YM-311 ()
FG2216 ()
FG 2216 ()
IOX3 ()
YM311 ()
P&D ID
PD004212
CAS
223387-75-5
Tags
available
drug candidate
covalent binder
Drug indication
Kidney disease
Drug Status
investigational
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION FG-2216 (IOX3) is a potent and orally active inhibitor of HIF prolyl hydroxylase-2 (PHD2), with an IC50 of 3.9 ¦ÌM. FG-2216 induces robust erythropoietin and modest fetal hemoglobin in vivo[1][2][3].
PRICE 33
DESCRIPTION FG-2216, also known as YM311, is orally bioavailable HIF-prolyl hydroxylase inhibitor. FG-2216 induced significant and reversible Epo induction in vivo. (BOC Sciences Bioactive Compounds)
DESCRIPTION FG-2216 (YM-311) is a potent HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme (IC50: 3.9 uM); orally bioavailable and induced reversible and significant Epo induction in vivo. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
15
AdooQ Bioactive Compound Library
A15530
Axon Medchem Screening Library
2570
BOC Sciences Bioactive Compounds
fg-2216-cas-223387-75-5-item-470907
Cayman Chemical Bioactives
18382
CovBinderInPDB
CBR000604
CBR000603
Drug Repurposing Hub
DrugBank
DB08687
DrugMAP
DM7RYL4
EU-OPENSCREEN Bioactive Compound Library
EOS100530
Mcule NIBR MoA Box Subset
MCULE-1504227616
MedChem Express Bioactive Compound Library
HY-15641
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
fg-2216
TargetMol Bioactive Compound Library
T2445
External IDs
27
Properties
(calculated by RDKit )
Molecular Weight
280.03
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
1.41
TPSA
99.52
Fraction CSP3
0.08
Chiral centers
0.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
HIF/HIF Prolyl-Hydroxylase
PHD2
EGLN1, EGLN2, HIF1A
PHD inhibitor
HIF
Member status
member
MOA
EGLN1 gene inhibitor
hypoxia inducible factor prolyl hydroxylase inhibitor
Pathway
Chromatin/Epigenetic
Metabolism
Metabolic Enzyme/Protease
Solubility
Soluble in DMSO, not in water
Source data