General
Preferred name
URACIL MUSTARD
Synonyms
Uracil mustard ()
uramustine ()
Uracil nitrogen mustard ()
Aminouracil mustard ()
5-[Di(2-chloroethyl)amino]uracil ()
Nordopan ()
5-[Bis(2-chloroethyl)amino]uracil ()
Uramustin ()
5-[Di(.beta.-chloroethyl)amino]uracil ()
2,6-Dihydroxy-5-bis[2-chloroethyl]aminopyrimidine ()
NSC-34462 ()
U-8344 ()
Uramustine ()
P&D ID
PD004125
CAS
66-75-1
Tags
available
drug
Approved by
FDA
First approval
1962
Drug Status
approved
withdrawn
Drug indication
Acute myeloid leukaemia
Antineoplastic
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Chemically uramustine is a derivative of nitrogen mustard and uracil. It is used clinically as a DNA alkylating anti-cancer chemotherapeutic.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
14
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
NIH Approved Oncology Drugs
ReFrame library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
24
Molecular Weight
251.02
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
1
Aromatic Ring Count
1
cLogP
0.35
TPSA
68.96
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
non-Hodgkin lymphoma (NHL)
MOA
DNA synthesis inhibitor
ATC
L01AD08
Therapeutic Class
Anticancer Agents
Source data
