General
Preferred name
PAZOPANIB HYDROCHLORIDE
Synonyms
Votrient HCl ()
Pazopanib HCl ()
GW786034 HCl ()
Pazopanib HCl (GW786034) ()
Pazopanib (Hydrochloride) ()
GW786034 (Hydrochloride) ()
Pazopanib HCl (GW786034 HCl) ()
GW786034B ()
Pazopanib (as hydrochloride) ()
Votrient ()
Pazopanib monohydrochloride ()
GW-786034B ()
P&D ID
PD004106
CAS
635702-64-6
444731-52-6
Tags
available
drug
Drug indication
Renal cell carcinoma
Sarcoma
Drug Status
approved
Max Phase
4.0
First approval
2009
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR¦Â, c-Kit, FGFR1, and c-Fms with an IC50 of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.
PRICE 40
DESCRIPTION Pazopanib Hydrochloride (Votrient HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. (TargetMol Bioactive Compound Library)
Compound Sets
10
AdooQ Bioactive Compound Library
A10699
Axon Medchem Screening Library
1420
ChEMBL Approved Drugs
CHEMBL1201733
ChEMBL Drugs
CHEMBL1201733
DrugMAP
DM6U9CQ
DrugMAP Approved Drugs
DM6U9CQ
MedChem Express Bioactive Compound Library
HY-12009
NIH Approved Oncology Drugs
48431568
Selleckchem Bioactive Compound Library
Pazopanib-Hydrochloride
TargetMol Bioactive Compound Library
T6930
External IDs
21
Properties
(calculated by RDKit )
Molecular Weight
473.14
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
4
cLogP
3.56
TPSA
119.03
Fraction CSP3
0.19
Chiral centers
0.0
Largest ring
6.0
QED
0.45
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Autophagy
c-Fms
c-Kit
FGFR
PDGFR
VEGFR
Multiple TKI
Autophagy,c-Kit,CSF-1R,FGFR,PDGFR,VEGFR
VEGFR1
VEGFR2
VEGFR3
Pathway
Angiogenesis
Tyrosine Kinase/Adaptors
Protein Tyrosine Kinase/RTK
Source data