General
Preferred name
VINCRISTINE SULFATE
Synonyms
22-Oxovincaleukoblastine sulfate ()
Leurocristine sulfate ()
Leurocristine ()
vincristine ()
Onkovin ()
Oncovin ()
VCR sulfate ()
Alkaloid extracted from Vinca rosea Linn ()
Vincasar ()
Vincrex ()
Kyocristine ()
NSC-67574 ()
Marqibo ()
Vincristine Sulfate Pfs ()
LILLY-37231 ()
37231 ()
Marqibo Kit ()
Vincrisul ()
Vincristini sulfas ()
Vincasar Pfs ()
Vincristine sulphate ()
Vincristine sulfate liposome ()
Novopharm ()
P&D ID
PD004084
CAS
2068-78-2
Tags
natural product
drug
available
Drug Status
approved
Max Phase
Phase 4
Drug indication
Antineoplastic
First approval
1963
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION p53 inhibitor. Also aryl hydrocarbon receptor agonist (Tocris Bioactive Compound Library)
DESCRIPTION Disrupts microtubules (Tocriscreen Total)
Cell lines
26
Organisms
1
Compound Sets
7
AdooQ Bioactive Compound Library
A10973
ChEMBL Approved Drugs
CHEMBL501867
ChEMBL Drugs
CHEMBL501867
NIH Approved Oncology Drugs
112141, 92764772
TargetMol Bioactive Compound Library
T1270
Tocris Bioactive Compound Library
1257
Tocriscreen Total
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
922.37
Hydrogen Bond Acceptors
14
Hydrogen Bond Donors
5
Rotatable Bonds
8
Ring Count
9
Aromatic Ring Count
3
cLogP
2.86
TPSA
245.77
Fraction CSP3
0.57
Chiral centers
10.0
Largest ring
9.0
QED
0.07
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Cytoskeletal Signaling
Target
Microtubule
Primary Target
Microtubules
MOA
Microtubule Associated
Source data