General
Preferred name
ZOLEDRONIC ACID
Synonyms
Zoledronic acid hydrate ()
CGP 42446 ()
CGP42446A ()
ZOL 446 ()
Zoledronate ()
CGP-4244 ()
Zometa ()
ZOLEDRONIC ACID ANHYDROUS ()
CPG 42446 ()
(1-Hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid ()
Phosphonic acid,[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis- ()
Zoledronate monohydrate ()
Zoledronate D,L-Lysine Monohydrate ()
Zoledronic acid (monohydrate) ()
Zoledronic Acid (Zoledronate) ()
ZOLEDRONATE DISODIUM ()
ZOLEDRONATE TRISODIUM ()
CGP 42446 monohydrate ()
CGP42446A monohydrate ()
ZOL 446 monohydrate ()
Zoledronic acid (ZOL 446) ()
ZA, Zoledronate, CGP-4244, GP42446A, ZOL 446, Zometa, Zomera, Aclasta, Reclast ()
Zoledronic ()
Zoledronate hydrate ()
Zoledronic acid accord ()
Zoladrona acid mylan ()
Zoledronic acid monohydrate ()
AK-156 ()
NSC-721517 ()
Zoledronic acid medac ()
Anhydrous zoledronic acid ()
Zerlinda ()
Reclast ()
Zoledronic acid teva ()
Aclasta ()
CGP-42446 ()
CGP-42446A ()
CGP 42446A ()
Zoledronate disodium tetrahydrate ()
Zoledronate disodium hydrate ()
CGP 42446B ()
CGP-42446B ()
Zoledronic Acid (hydrate) ()
P&D ID
PD004076
CAS
118072-93-8
165800-06-6
165800-08-8
Tags
drug candidate
natural product
probe
drug
available
Approved by
EMA
FDA
First approval
2001
Drug Status
investigational
approved
Drug indication
Osteoporosis Therapy Adjunct
Bone Resorption Inhibitor
Osteoporosis Therapy Adjunct,Osteoporosis Therapy Adjunct,Osteoporosis Therapy Adjunct
Hypercalcaemia
Max Phase
Phase 4
Probe info
Probe selectivity
protein-selective
Probe type
P&D approved
calculated probe
Probe sources
High-quality chemical probes
Probe Miner (suitable probes)
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Marketed formulations may contain zoledronic acid monohydrate (PubChem CID 121586). (GtoPdb)
DESCRIPTION Potent and selective allosteric activator of AMPK (Tocris Bioactive Compound Library)
DESCRIPTION Zoledronic acid (zoledronate) is a bisphosphonate bone resorption inhibitor, an inhibitor of farnesyl diphosphate (FPP) synthase which results in downstream inhibition of osteoclast activity and reduced bone resorption and turnover. It has been used to treat postmenopausal osteoporosis, Paget's disease, hypercalcemia, and along with cancer chemotherapy to treat bone damage caused by cancer that has spread to the bones. (BOC Sciences Bioactive Compounds)
DESCRIPTION Zoledronic acid induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such as Ras and Rho. (BOC Sciences Bioactive Compounds)
Cell lines
15
Organisms
6
Compound Sets
35
AdooQ Bioactive Compound Library
A11010
BOC Sciences Bioactive Compounds
zoledronic-acid-hydrate-cas-165800-06-6-60466
zoledronic-acid-cas-118072-93-8-item-84-82164
Cayman Chemical Bioactives
14984
ChEMBL Approved Drugs
CHEMBL924
ChEMBL Drugs
CHEMBL924
CHEMBL2103912
CHEMBL3989655
Concise Guide to Pharmacology 2017/18
3177
Concise Guide to Pharmacology 2019/20
3177
Concise Guide to Pharmacology 2021/22
3177
Concise Guide to Pharmacology 2023/24
3177
Drug Repurposing Hub
DrugBank
DB00399
DB16907
DrugBank Approved Drugs
DB00399
DB16907
DrugCentral
2868
DrugCentral Approved Drugs
2868
DrugMAP
DMIXC7G
DrugMAP Approved Drugs
DMIXC7G
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
3177
High-quality chemical probes
PD004076
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL924
Mcule NIBR MoA Box Subset
MCULE-1604726355
MedChem Express Bioactive Compound Library
HY-13777A
HY-13777
NCATS Inxight Approved Drugs
70HZ18PH24
NIH Approved Oncology Drugs
536160
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
Probe Miner (suitable probes)
P14324/65742
ReFrame library
Selleckchem Bioactive Compound Library
Zoledronic-Acid
TargetMol Bioactive Compound Library
T6739
The Spectrum Collection
Tocris Bioactive Compound Library
6111
ZINC Tool Compounds
ZINC000003803652
External IDs
74
Properties
(calculated by RDKit )
Molecular Weight
272.0
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
5
Rotatable Bonds
4
Ring Count
1
Aromatic Ring Count
1
cLogP
-1.12
TPSA
153.11
Fraction CSP3
0.4
Chiral centers
0.0
Largest ring
5.0
QED
0.43
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Cell Cycle/Checkpoint
Anti-infection
Apoptosis
Autophagy
Target
Rho
FDPS, GGPS1
Bacterial
Apoptosis related,Autophagy,Ras,Rho
Primary Target
Other Synthases/Synthetases
MOA
Inhibitor
Angiogenesis Inhibitors
bone resorption inhibitor
Member status
member
Indication
Paget's disease
Therapeutic Class
Bone Density Conservation Agents
Source data