General
Preferred name
WP1130
Synonyms
WP 1130 ()
WP-1130 ()
Degrasyn ()
Degrasyn (WP1130) ()
P&D ID
PD003660
CAS
856243-80-6
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Degrasyn (WP1130) is a cell-permeable deubiquitinase (DUB) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37. Degrasyn has been shown to downregulate the antiapoptotic proteins Bcr-Abl and JAK2.
PRICE 79
DESCRIPTION inhibitor of the deubiquitinase activity of USP9X, USP5, USP14, and UCH37 (Informer Set)
DESCRIPTION Degrasyn (WP1130) (WP1130), a specific deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor, also inhibits Bcr/Abl, which is a JAK2 transducer (without affecting 20S proteasome) and activator of transcription (STAT). (TargetMol Bioactive Compound Library)
Cell lines
3
Organisms
0
Compound Sets
10
AdooQ Bioactive Compound Library
A10988
Axon Medchem Screening Library
1779
Cayman Chemical Bioactives
15227
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
Informer Set
660432
LINCS compound set
10558-101
MedChem Express Bioactive Compound Library
HY-13264
Selleckchem Bioactive Compound Library
WP1130
TargetMol Bioactive Compound Library
T6300
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
383.06
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
4.41
TPSA
65.78
Fraction CSP3
0.21
Chiral centers
1.0
Largest ring
6.0
QED
0.46
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
UCHL5
USP14
USP5
USP9X
JAK2, UCHL5, USP14, USP9X
DUB inhibitor
Bcr-Abl
Deubiquitinase
Apoptosis related,Autophagy,Bcr-Abl,DUB
Compound status
probe
Pathway
Angiogenesis
Apoptosis
Autophagy
Cell Cycle/Checkpoint
Chromatin/Epigenetic
Cytoskeletal Signaling
DNA Damage/DNA Repair
JAK/STAT Signaling
Stem Cells
Tyrosine Kinase/Adaptors
Ubiquitination
Cell Cycle/DNA Damage
Protein Tyrosine Kinase/RTK
MOA
Deubiquitinase inhibitor
Source data