General
Preferred name
PCI-34051
Synonyms
BRD-K88742110 ()
PCI 34051 ()
P&D ID
PD003631
CAS
950762-95-5
Tags
available
drug candidate
obsolete probe
Drug indication
Solid tumour/cancer
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
PCI-34051 is a potent and selective HDAC8 inhibitor with IC50 of 10 nM, with >200-fold selectivity over the other HDAC isoforms.
PRICE
62
DESCRIPTION
inhibitor of HDAC8
(Informer Set)
DESCRIPTION
Pan protein kinase D (PKD) inhibitor; cell permeable
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent and selective HDAC8 inhibitor
(Tocriscreen Plus)
DESCRIPTION
PCI-34051 is a potent, histone deacetylase 8 (HDAC8)-specific inhibitor with >200-fold selectivity over the other HDAC isoforms. PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias, but not in other hematopoietic or solid tumor lines. Unlike broad-spectrum HDAC inhibitors, PCI-34051 does not cause detectable histone or tubulin acetylation. PCI-34051 could offer benefits including a greater therapeutic index for treating T-cell malignancies.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
PCI-34051 is an effective and selective HDAC8 inhibitor (IC50: 10 nM).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
29
Organisms
1
Compound Sets
17
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Drug Repurposing Hub
DrugMAP
EUbOPEN Chemogenomics Library
Informer Set
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Obsolete Compounds
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
296.12
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
3
cLogP
2.82
TPSA
63.49
Fraction CSP3
0.12
Chiral centers
0.0
Largest ring
6.0
QED
0.57
QED
0.57
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Target
HDAC8
Apoptosis
HDAC
HDAC1
HDAC10
HDAC2
HDAC6
HDAC1, HDAC10, HDAC6, HDAC8
Apoptosis related,HDAC
Compound status
probe
Target Type
Enzymes
Primary Target
Class I HDACs
MOA
Inhibitor
HDAC8 inhibitor
HDAC inhibitor
Member status
virtual
Pathway
Chromatin/Epigenetic
DNA Damage/DNA Repair
Cell Cycle/DNA Damage
Epigenetics
Recommended Cell Concentration
1 uM
Source data
