General
Preferred name
PANOBINOSTAT
Synonyms
LBH-589 ()
NVP-LBH589 ()
LBH589 ()
LBH589 (Panobinostat) ()
LBH 589 ()
NVP-LBH-589 ()
Farydak ()
P-3703 ()
A-1025 ()
PANOBINOSTAT LACTATE ()
Panobinostat (LBH589) ()
Panobinostat hydrate ()
Panobinostat lactate anhydrous ()
Panobinostat-d4 ()
P&D ID
PD003575
CAS
404950-80-7
Tags
obsolete probe
nuisance
natural product
drug
available
Approved by
EMA
FDA
First approval
2015
Drug Status
investigational
approved
Drug indication
Primary myelofibrosis
Multiple myeloma
Type-2 diabetes
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Panobinostat is a non-selective histone deacetylase (HDAC) inhibitor . The compound also has antimalarial activity.
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
DESCRIPTION
inhibitor of HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8
(Informer Set)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
22
Organisms
2
Compound Sets
27
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
Informer Set
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Approved Oncology Drugs
Novartis Chemogenetic Library (NIBR MoA Box)
Nuisance compounds in cellular assays
NURSA ligand set
Obsolete Compounds
Pandemic Response Box
Reference compounds for characterizing cellular injury in high-content cellular morphology assays
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
52
Molecular Weight
349.18
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
4
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
3
cLogP
3.33
TPSA
77.15
Fraction CSP3
0.19
Chiral centers
0.0
Largest ring
6.0
QED
0.23
Structural alerts
2
historic compounds (Chemical Probes.org)
Obsolete
Nonspecific HDAC inhibiton
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Target
HDAC1
HDAC2
HDAC3
HDAC6
HDAC8
HDAC
HDAC1, HDAC2, HDAC3, HDAC4, HDAC6, HDAC7, HDAC8, HDAC9
HIV
Apoptosis related,Autophagy,HDAC,HIV Protease
Compound status
clinical
Pathway
Chromatin/Epigenetic
DNA Damage/DNA Repair
Anti-infection
Apoptosis
Autophagy
Cell Cycle/DNA Damage
Epigenetics
Member status
virtual
MOA
HDACs
Apoptosis Inducers
Histone Deacetylase (HDAC) Inhibitors
HDAC inhibitor
Indication
multiple myeloma
Source data
