General
Preferred name
HC-067047
Synonyms
HC 067047 ()
HC067047 ()
P&D ID
PD003568
CAS
883031-03-6
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
inhibitor of cation channel TRPV4
(Informer Set)
DESCRIPTION
Potent and selective TRPV4 antagonist
(Tocriscreen Plus)
DESCRIPTION
Potentiator of NMDA receptors containing GluN2C/GluN2D
(Tocris Bioactive Compound Library)
DESCRIPTION
HC-067047 is a potent and selective TRPV4 antagonist. It has been shown to increase functional bladder capacity and to reduce micturition frequency in wild-type mice and rats with cystitis. HC-067047 also attenuated allodynia in diabetic mice, suggesting its potential application for the treatment of painful diabetic neuropathy (PDN).
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
18
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Informer Set
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
14
Molecular Weight
471.21
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
4
Aromatic Ring Count
3
cLogP
5.46
TPSA
46.5
Fraction CSP3
0.35
Chiral centers
0.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
TRPV4
hTRPV4/mTRPV4
TRP Channel
Compound status
probe
Target Type
Ion Channels
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Primary Target
TRPV
MOA
TRP/TRPV Channel
Antagonist
TRPV4 gene inhibitor
transient receptor potential channel antagonist
Member status
member
Source data
