General
Preferred name
BIBR1532
Synonyms
BIBR-1532 ()
BIBR 1532 ()
P&D ID
PD003565
CAS
321674-73-1
Tags
available
free of charge
probe
Probe info
Probe type
experimental probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Orthogonal probes
1
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
BIBR1532 is a potent, non-nucleosidic inhibitor of the native and recombinant human telomerase. The small molecule induces telomere shortening by interfering with the processivity of the enzyme while lacking acute cytotoxicity. BIBR1532 shows excellent selectivity and due to its good bioavailability and high plasma exposure levels, the compound can be used as a tool for in vitro as well as in vivo studies. BIBR1532 induces a senescence phenotype and anti-proliferative effects demonstrated by growth arrest in various cancer cell lines. It has also shown effects on tumor growth in immunodeficient NMRI mice. With BIBR1654 a negative control is also available.
(opnMe Portal)
DESCRIPTION
inhibitor of telomerase reverse transcriptase
(Informer Set)
DESCRIPTION
Selective telomerase inhibitor
(Tocriscreen Plus)
DESCRIPTION
Broad spectrum MMP inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM.BIBR1132 is highly selective for inhibition of telomerase, resulting in delayed growth arrest of tumor cells. Treatment of cancer cells with BIBR1532 leads to progressive telomere shortening, consecutive telomere dysfunction, and finally growth arrest after a lag period that is largely dependent on initial telomere length.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
8
Organisms
0
Compound Sets
13
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Drug Repurposing Hub
High-quality chemical probes
Informer Set
MedChem Express Bioactive Compound Library
opnMe Portal
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
17
Molecular Weight
331.12
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
3
cLogP
4.58
TPSA
66.4
Fraction CSP3
0.05
Chiral centers
0.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
TERT
Telomerase
Apoptosis related,Telomerase
Compound status
probe
Target Type
Enzymes
Pathway
DNA Damage/DNA Repair
Apoptosis
Cell Cycle/DNA Damage
MOA
Inhibitor
Telomerase inhibitor
Source data
