General
Preferred name
Am 580
Synonyms
AM-580 ()
AM580 ()
CD336 ()
NSC608001 ()
Ro 40-6055 ()
PMID27336223-Compound-5 ()
P&D ID
PD003554
CAS
102121-60-8
Tags
drug candidate
natural product
available
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Ro 40-6055 (Am580) is a retinoic acid analogue that acts as a selective retinoic acid receptor α (RARα) agonist . (GtoPdb)
DESCRIPTION agonist of retinoic acid receptor alpha (Informer Set)
DESCRIPTION Retinoic acid analog; RARalpha agonist (Tocriscreen Plus)
DESCRIPTION Retinoic acid analog; RAR agonist (Tocris Bioactive Compound Library)
DESCRIPTION Retinoic acid analog; RARα agonist (Tocriscreen Total)
Compound Sets
23
AdooQ Bioactive Compound Library
A11792
Axon Medchem Screening Library
2948
Cayman Chemical Bioactives
15261
Concise Guide to Pharmacology 2017/18
2647
Concise Guide to Pharmacology 2019/20
2647
Concise Guide to Pharmacology 2021/22
2647
Concise Guide to Pharmacology 2023/24
2647
Drug Repurposing Hub
DrugMAP
DM6E50A
DMU2EKN
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS101509
EUbOPEN Chemogenomics Library
Guide to Pharmacology
2647
Informer Set
58455
MedChem Express Bioactive Compound Library
HY-10475
NURSA ligand set
nursa/index.jsf?doi=10.1621%2FZA9Z1YGHZP
ReFrame library
Selleckchem Bioactive Compound Library
am580
TargetMol Bioactive Compound Library
T5854
Tocris Bioactive Compound Library
0760
Tocriscreen Plus
0760
Tocriscreen Total
ZINC Tool Compounds
ZINC000003784077
External IDs
26
Properties
(calculated by RDKit )
Molecular Weight
351.18
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
4.99
TPSA
66.4
Fraction CSP3
0.36
Chiral centers
0.0
Largest ring
6.0
QED
0.82
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
RARA
RAR??
RAR-a agonist
RAR/RXR
Retinoid Receptor
Compound status
probe
Target Type
Nuclear Receptors
Pathway
Metabolism
Autophagy
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Primary Target
Retinoic Acid Receptors
MOA
Agonist
Retinoid Receptor agonist
Source data