General
Preferred name
BMS-754807
Synonyms
BMS 754807 ()
BMS754807 ()
P&D ID
PD003530
CAS
1001350-96-4
Tags
available
drug candidate
Drug Status
investigational
Max Phase
Phase 2
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION BMS-754807 is an orally bioavailable antagonist of human insulin-like growth factor type I receptor (IGF-1R) with potential antineoplastic activity. Its discovery is described in Wittman et al. (2009) , where it is compound 9d. (GtoPdb)
DESCRIPTION inhibitor of insulin-like growth factor 1 receptor and insulin receptor (Informer Set)
DESCRIPTION BMS-754807 is an orally bioavailable antagonist of human insulin-like growth factor type I receptor (IGF-1R) with potential antineoplastic activity. BMS-7548077 binds to IGF-1R, preventing IGF-1 ligand binding and activation of IGF-1R-mediated signaling pathways. (BOC Sciences Bioactive Compounds)
Cell lines
601
Organisms
0
Compound Sets
26
AdooQ Bioactive Compound Library
A11059
BOC Sciences Bioactive Compounds
bms-754807-cas-1001350-96-4-item-84-307711
Cayman Chemical Bioactives
17505
ChEMBL Drugs
CHEMBL575448
Clinical kinase drugs
Concise Guide to Pharmacology 2017/18
7952
Concise Guide to Pharmacology 2019/20
7952
Concise Guide to Pharmacology 2021/22
7952
Concise Guide to Pharmacology 2023/24
7952
Drug Repurposing Hub
DrugBank
DB15399
DrugMAP
DMPK32V
EU-OPENSCREEN Bioactive Compound Library
EOS100581
Guide to Pharmacology
7952
Informer Set
417981
LINCS compound set
10290-101
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL575448
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
CHEMBL575448
Mcule NIBR MoA Box Subset
MCULE-1280727687
MedChem Express Bioactive Compound Library
HY-10200
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
BMS-754807
TargetMol Bioactive Compound Library
T2349
Welcome Trust Cancer Drugs
184
ZINC Tool Compounds
ZINC000043203317
External IDs
28
Properties
(calculated by RDKit )
Molecular Weight
461.21
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
6
Aromatic Ring Count
4
cLogP
3.61
TPSA
116.13
Fraction CSP3
0.35
Chiral centers
1.0
Largest ring
6.0
QED
0.38
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
IGF1R
MET
IGF-1R
Insulin Receptor
TrkA
TrkB
AKT1, IGF1R
c-Met,IGF-1R,RON,Trk receptor
Compound status
probe
Pathway
IGFR signaling
Tyrosine Kinase/Adaptors
Protein Tyrosine Kinase/RTK
Targets
IGF1R,INSR
Member status
member
MOA
IGF-1R Inhibitors
IGF-1 inhibitor
Source data