General
Preferred name
SCH-79797
Synonyms
SCH 79797 dihydrochloride ()
SCH79797 ()
SCH79797 (dihydrochloride) ()
SCH79797 dihydrochloride ()
SCH 79797 (hydrochloride) ()
P&D ID
PD003515
CAS
1216720-69-2
245520-69-8
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Potent, selective non-peptide PAR1 antagonist. Marketed as SCH-79797 dihydrochloride.

Other biological activity: SCH-79797 has been reported to exhibit antibacterial activity against Gram-positive and -negative bacteria, including MRSA and other clinically significant bacterial pathogens, with a low frequency of resistance in vivo . The authors show that SCH-79797 targets both bacterial folate metabolism and membrane integrity to mediate its antibacterial effect. (GtoPdb)
DESCRIPTION SCH79797 is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 inhibits thrombin-induced platelet aggregation with an IC50 of 3 ¦ÌM. SCH79797 has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes[1][2][3][4].
DESCRIPTION SCH79797 dihydrochloride is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 dihydrochloride inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride inhibits thrombin-induced platelet aggregation with an IC50 of 3 ¦ÌM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 dihydrochloride also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes[1][2][3][4].
PRICE 108
DESCRIPTION antagonist of proteinase-activated receptor 1 (PAR1) (Informer Set)
DESCRIPTION Inhibits glutamate release. Anticonvulsant (Tocris Bioactive Compound Library)
DESCRIPTION SCH79797 dihydrochloride is an effective and selective antagonist of protease activated receptor 1 (PAR1) with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
12
Axon Medchem Screening Library
1275
Cayman Chemical Bioactives
14633
Concise Guide to Pharmacology 2021/22
10971
Concise Guide to Pharmacology 2023/24
10971
CZ-OPENSCREEN Bioactive Library
Guide to Pharmacology
10971
Informer Set
375264
MedChem Express Bioactive Compound Library
HY-14993
HY-14994
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
sch79797-dihydrochloride
TargetMol Bioactive Compound Library
T12870
Tocris Bioactive Compound Library
1592
External IDs
27
Properties
(calculated by RDKit )
Molecular Weight
371.21
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
5
Aromatic Ring Count
4
cLogP
4.91
TPSA
68.76
Fraction CSP3
0.3
Chiral centers
0.0
Largest ring
6.0
QED
0.52
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
F2R
PAR-1
Apoptosis
Protease-Activated Receptor (PAR)
Protease Activated Receptor (PAR)
PAR
Compound status
probe
Primary Target
Protease-Activated Receptors
MOA
Antagonist
F2R antagonist
PAR1 antagonist
Member status
member
Pathway
GPCR/G protein
Source data