General
Preferred name
STAUROSPORINE
Synonyms
AM-2282 ()
Antibiotic AM-2282 ()
CGP 41251 ()
STS ()
Staurosporine (AM-2282) ()
Antibiotic AM-2282, STS ()
P&D ID
PD003511
CAS
62996-74-1
109189-95-9
Tags
obsolete probe
nuisance
covalent binder
natural product
drug candidate
available
Drug indication
Discovery agent
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Staurosporine is a non-specific, ATP-competitive inhibitor of protein kinase C (PKC) isolated from a Streptomyces strain . It inhibits all PKC enzyme isoforms , but has a more potent inhibitory effect on PKCs associated with the cell membrane compared to cytosolic PKCs.
Staurosporine analogues such as and are being investigated as therapeutics. (GtoPdb)
DESCRIPTION inhibitor of multiple kinases (Informer Set)
Cell lines
63
Organisms
3
Compound Sets
17
AdooQ Bioactive Compound Library
A10864
Cayman Chemical Bioactives
81590
CovalentInDB
CI000044
DrugBank
DB02010
DrugMAP
DM0E9BR
Guide to Pharmacology
346
Informer Set
50769
LINCS compound set
10103-999
10103-101
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL388978
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
CHEMBL388978
MedChem Express Bioactive Compound Library
HY-15141
Novartis Chemogenetic Library (NIBR MoA Box)
Nuisance compounds in cellular assays
Obsolete Compounds
staurosporine
Reference compounds for characterizing cellular injury in high-content cellular morphology assays
Selleckchem Bioactive Compound Library
Staurosporine
TargetMol Bioactive Compound Library
T6680
External IDs
31
Properties
(calculated by RDKit )
Molecular Weight
466.2
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
8
Aromatic Ring Count
5
cLogP
4.35
TPSA
69.45
Fraction CSP3
0.32
Chiral centers
4.0
Largest ring
7.0
QED
0.41
Structural alerts
2
historic compounds (Chemical Probes.org)
Obsolete
Nonspecific kinase inhibiton
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Compound status
probe
Pathway
Angiogenesis
Cytoskeletal Signaling
Anti-infection
Apoptosis
Epigenetics
Stem Cell/Wnt
TGF-beta/Smad
Target
PKC
PKC??
c-Fgr
antibiotic
Bacterial
Fungal
PKA
ADC Cytotoxin,Antineoplastic and Immunosuppressive Antibiotics,CaMK,PKA,PKC,PKG,S6 Kinase
Member status
virtual
MOA
Signal transduction modulator
Protein Kinase C (PKC) Inhibitors
"Signal transduction modulator
Protein Kinase C (PKC) Inhibitors"
Cellular injury category
Kinase
Source data