General
Preferred name
MK-0752
Synonyms
MK0752 ()
P&D ID
PD003509
CAS
471905-41-6
Tags
available
drug candidate
Drug Status
investigational
Max Phase
Phase 1
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION inhibitor of gamma-secretase (Informer Set)
Compound Sets
9
Cayman Chemical Bioactives
16706
ChEMBL Drugs
CHEMBL4205422
Drug Repurposing Hub
DrugBank
DB12852
Informer Set
660332
MedChem Express Bioactive Compound Library
HY-10974
ReFrame library
Selleckchem Bioactive Compound Library
mk-0752
TargetMol Bioactive Compound Library
T2625
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
442.08
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
2
cLogP
5.34
TPSA
71.44
Fraction CSP3
0.38
Chiral centers
0.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
APH1A
NCSTN
PSEN1
PSENEN
¦Ã-secretase
A??
??secretase
A¦Â
γ-secretase
Beta Amyloid,Secretase
Compound status
clinical
Pathway
Neuroscience
Proteases/Proteasome
Stem Cells
Neuronal Signaling
Stem Cell/Wnt
MOA
Beta Amyloid inhibitor
gamma secretase inhibitor
Source data