General
Preferred name
KU-55933
Synonyms
KU 55933 ()
KU55933 ()
ATM Kinase Inhibitor ()
KU-55933 (ATM Kinase Inhibitor) ()
P&D ID
PD003488
CAS
587871-26-9
Tags
available
probe
drug candidate
Drug indication
Solid tumour/cancer
Probe info
Probe type
P&D approved
calculated probe
Probe selectivity
protein-selective
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
1
No orthogonal probes found
Similar probes
1
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
KU-55933 is a potent and selective inhibitor of the ataxia-telangiectasia mutated (ATM) kinase , used to investigate the DNA damage repair response, particularly in relation to exploiting this pathway to discover novel cancer therapeutics.
(GtoPdb)
DESCRIPTION
KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 12.9 and 2.2 nM, respectively, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.
PRICE
53
DESCRIPTION
inhibitor of ataxia telangiectasia mutated (ATM)
(Informer Set)
DESCRIPTION
DNA ligase I, III and IV inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent and selective ATM kinase inhibitor
(Tocriscreen Total)
DESCRIPTION
KU-55933 is an ATM inhibitor, which blocks the phosphorylation of Akt induced by insulin and insulin-like growth factor I in cancer cells that exhibit abnormal Akt activity. Moreover, KU-55933 inhibits cancer cell proliferation by inducing G(1) cell cycle arrest. It does so through the downregulation of the synthesis of cyclin D1, a protein known to be elevated in a variety of tumors. In addition, KU-55933 treatment during serum starvation triggers apoptosis in these cancer cells. Research results suggest that KU-55933 may be a novel chemotherapeutic agent targeting cancer resistant to traditional chemotherapy or immunotherapy due to aberrant activation of Akt. Furthermore, KU-55933 completely abrogates rapamycin-induced feedback activation of Akt. Combination of KU-55933 and rapamycin not only induces apoptosis, which is not seen in cancer cells treated only with rapamycin, but also shows better efficacy in inhibiting cancer cell proliferation than each drug alone.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
KU-55933 (ATM Kinase Inhibitor) is an ATM inhibitor (IC50=12.9 nM; Ki=2.2 nM) that is selective and ATP-competitive. KU-55933 induces apoptosis and has antitumor effects.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
204
Organisms
1
Compound Sets
22
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
High-quality chemical probes
Informer Set
JUMP-Target 1 Compound Set
LINCS compound set
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Probe Miner (suitable probes)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
Welcome Trust Cancer Drugs
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
28
Molecular Weight
395.06
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
5
Aromatic Ring Count
3
cLogP
4.76
TPSA
42.68
Fraction CSP3
0.19
Chiral centers
0.0
Largest ring
6.0
QED
0.49
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
ATM
ATM/ATR
Autophagy
ATM, PRKDC
ATM inhibitor
ATM/ATR,Autophagy,ULK
ATR
DNA-PK
MTOR
PI3K
Compound status
probe
Pathway
Genome integrity
DNA Damage/DNA Repair
PI3K/Akt/mTOR signaling
Cell Cycle/DNA Damage
PI3K/Akt/mTOR
Primary Target
ATM and ATR Kinases
MOA
Inhibitor
ATM Kinase Inhibitors
DNA Repair Inhibitors
ATM kinase inhibitor
Member status
member
Source data
