General
Preferred name
PIK-93
Synonyms
PIK 93 ()
N-(5-{4-Chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl}-4-methyl-1,3-thiazol-2-yl)acetamide ()
P&D ID
PD003469
CAS
593960-11-3
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION PIK-93 is the first potent, synthetic PI4K (PI4KIII¦Â) inhibitor with IC50 of 19 nM, and also inhibits PI3K¦Ã and PI3K¦Á with IC50 of 16 nM and 39 nM, respectively.
PRICE 104
DESCRIPTION PIK-93, the first potent synthetic PI4K inhibitor, exhibits an IC50 of 19 nM and also inhibits PI3K?? with an IC50 of 39 nM.
DESCRIPTION inhibitor of PI3K catalytic subunit gamma (Informer Set)
DESCRIPTION PIK-93 is a potent PI3K inhibitor. (BOC Sciences Bioactive Compounds)
DESCRIPTION PIK-93, the first potent synthetic PI4K inhibitor, exhibits an IC50 of 19 nM and also inhibits PI3Kα with an IC50 of 39 nM. (TargetMol Bioactive Compound Library)
DESCRIPTION Selective 12/15 LOX inhibitor; active in vivo (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
4
Compound Sets
20
AdooQ Bioactive Compound Library
A10731
BOC Sciences Bioactive Compounds
pik-93-cas-593960-11-3-item-84-95186
Cayman Chemical Bioactives
10009212
Concise Guide to Pharmacology 2017/18
6062
Concise Guide to Pharmacology 2019/20
6062
Concise Guide to Pharmacology 2021/22
6062
Concise Guide to Pharmacology 2023/24
6062
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB06836
DrugMAP
DM3JBLK
EU-OPENSCREEN Bioactive Compound Library
EOS100640
Guide to Pharmacology
6062
Informer Set
660774
LINCS compound set
10190-101
MedChem Express Bioactive Compound Library
HY-12046
Selleckchem Bioactive Compound Library
PIK-93
TargetMol Bioactive Compound Library
T2616
Tocris Bioactive Compound Library
6440
Welcome Trust Cancer Drugs
303
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
389.03
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
2.0
TPSA
108.39
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.7
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
PIK3CG
PI3K
PI4K
Virus Protease
PI4K,PI3K
PI4KB, PIK3C3, PIK3CG
ATM
C2β
DNA-PK
hsVps34
mTORC1
p110α
p110β
p110γ
p110δ
PI3KIIIβ
Compound status
probe
Pathway
PI3K signaling
DNA Damage/DNA Repair
Metabolism
Microbiology/virology
PI3K/Akt/mTOR signaling
Anti-infection
PI3K/Akt/mTOR
Primary Target
PI 3-kinase
MOA
Inhibitor
PI3K inhibitor
Solubility
In vitro:<br/>10 mM in DMSO
Source data