General
Preferred name
AGK2
Synonyms
AGK-2 ()
AGK-2 HCl ()
AGK2 hydrochloride ()
P&D ID
PD003459
CAS
304896-28-4
2138805-02-2
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION AGK2 is a selective sirtuin 2 (SIRT2) inhibitor . The sirtuins are members of the histone deacetylase family.
The SIRT histone deacetylases have been implicated in a wide range of cellular processes including stress resistance, metabolism, differentiation, and aging . (GtoPdb)
DESCRIPTION AGK2 is a selective SIRT2 inhibitor with an IC50 of 3.5 ¦ÌM. AGK2 inhibits SIRT1 and SIRT3 with IC50s of 30 and 91 ¦ÌM, respectively.
DESCRIPTION inhibitor of sirtuin 2 (Informer Set)
DESCRIPTION AGK2 is a selective SIRT2 and SIRT1. (Enamine Bioactive Compounds)
Cell lines
1
Organisms
0
Compound Sets
10
AdooQ Bioactive Compound Library
A14225
Cayman Chemical Bioactives
13145
CZ-OPENSCREEN Bioactive Library
DrugMAP
DM26AMU
Enamine Bioactive Compounds
EBC-180058
Enamine BioReference Compounds
Guide to Pharmacology
8099
Informer Set
411716
MedChem Express Bioactive Compound Library
HY-100578
Novartis Chemogenetic Library (NIBR MoA Box)
External IDs
20
Properties
(calculated by RDKit )
Molecular Weight
433.04
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
4
cLogP
6.35
TPSA
78.92
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.3
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
SIRT2
Sirtuin
Compound status
probe
Member status
member
MOA
SIRT inhibitor NAD dependent
Pathway
Apoptosis
Cell Cycle/DNA Damage
Epigenetics
Source data