General
Preferred name
DASATINIB
Synonyms
KIN001-005 ()
Sprycel, BMS-354825-03, BMS-354825 ()
BMS-354825 ()
Sprycel ()
Dasatinib (BMS-354825) ()
Dasatinib Monohydrate ()
DASATINIB ANHYDROUS ()
N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide, monohydrate ()
Dasatinib (hydrochloride) ()
Dasatinib (monohydrate) ()
BMS-354825 HYDRATE ()
BMS-354825-03 ()
DASATINIB HYDRATE ()
NSC-759877 ()
BMS-354825 (hydrochloride) ()
BMS-354825 (monohydrate) ()
Dasatinib hydrochloride ()
BMS-354825 Monohydrate ()
BMS-354825 HCl ()
Dasatinib monohydrate ()
Dasatinib-d8 ()
P&D ID
PD003446
CAS
302962-49-8
863127-77-9
854001-07-3
1132093-70-9
Tags
obsolete probe
natural product
drug
available
Approved by
EMA
FDA
First approval
2006
Drug Status
investigational
approved
Drug indication
Multiple myeloma
Severe acute respiratory syndrome (SARS)
Parkinson disease
Chronic myelogenous leukaemia
Middle East Respiratory Syndrome (MERS)
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Dasatinib is a Type-1 kinase inhibitor and was first approved by the FDA in 2006.
(GtoPdb)
DESCRIPTION
For the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy. Also indicated for the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to prior therapy.
(PKIDB)
DESCRIPTION
inhibitor of SRC, YES1, EPHA2, c-KIT, and LCK
(Informer Set)
DESCRIPTION
Dynamin-related GTPase DRP1 partial inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Dasatinib hydrochloride is a potent and dual Abl/ Src inhibitor. It inhibits c-Kit (WT)/c-Kit (D816V).
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Dasatinib Monohydrate is a novel, potent and multi-targeted inhibitor that targets Abl, PDGFR, ephrin receptors, Src, c-Kit, and other Src-family kinases (LCK, HCK, FYN, and others)
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
278
Organisms
4
Compound Sets
38
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
Clinical kinase drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP Approved Drugs
Enamine BioReference Compounds
Guide to Pharmacology
Informer Set
LSP-MoA library (Laboratory of Systems Pharmacology)
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
NIH Approved Oncology Drugs
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Obsolete Compounds
PKIDB
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Welcome Trust Cancer Drugs
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
73
Molecular Weight
487.16
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
3
Rotatable Bonds
7
Ring Count
4
Aromatic Ring Count
3
cLogP
3.31
TPSA
106.51
Fraction CSP3
0.36
Chiral centers
0.0
Largest ring
6.0
QED
0.47
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Target
EPHA2
KIT
LCK
SRC
YES1
ABL, SRC, KIT, PDGFR
ABL
c-Kit (D816V)
c-Kit (wt)
ABL1, ABL2, BLK, EPHA2, FGR, FRK, FYN, HCK, KIT, LCK, LYN, PDGFRB, SRC, SRMS, STAT5B, YES1
Bcr-Abl/Src inhibitor
ABL1
PDGFRB
ABL2
Fyn
Apoptosis related,Autophagy,Bcr-Abl,c-Kit,Src
Bcr-Abl,c-Kit,Src
Bcr-Abl,kit,Src
Compound status
FDA
Pathway
ABL signaling
Angiogenesis
Tyrosine Kinase/Adaptors
Cytoskeletal Signaling
Apoptosis
Autophagy
Protein Tyrosine Kinase/RTK
Targets
ABL1,SRC
Primary Target
Src Kinases
MOA
Bcr-Abl
c-Kit
Src
Inhibitor
Src Kinase Inhibitors
Inhibitors of Signal Transduction Pathways
Bruton's Tyrosine Kinase (BTK) Inhibitors
Bcr-Abl Kinase Inhibitors
Bcr-Abl kinase inhibitor, ephrin inhibitor, KIT inhibitor, PDGFR tyrosine kinase receptor inhibitor, SRC inhibitor, tyrosine kinase inhibitor
Member status
virtual
Indication
chronic myeloid leukemia (CML), acute lymphoblastic leukemia (ALL)
Therapeutic Indication
Anticancer
Therapeutic Class
Anticancer Agents
Antiviral Agents
VGSC Target
Nav1.5
Solubility
Soluble in DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated)
Source data
