General
Preferred name
MITOMYCIN
Synonyms
mitomycin C ()
Mytozytrex,NSC-26980 ()
MitoExtra ()
Mitonco ()
Mitomycin C from Streptomyces caespitosus ()
MitomycinMitomycin CMutamycin7-Amino-9.alpha.-methoxymitosaneAmetycineMitomycinumMMCMit-CMito-CAmetycin ()
NSC-26980 ()
Jelmyto ()
Mitozytrex ()
Mytozytrex ()
Mitomycine ()
Muamycin ()
UGN-101 ()
Mitomycin C ()
Mitocin-c ()
Mitosol ()
Mutamycin ()
Ugn-102 ()
Ametycine ()
Mitomicina ()
Mitomycin-c ()
P&D ID
PD003405
CAS
50-07-7
144085-53-0
1404-00-8
Tags
available
prodrug
drug
natural product
Approved by
PMDA
FDA
First approval
1981
Drug indication
Breast cancer
Gastrointestinal cancer
Neoplasm
Solid tumour/cancer
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Mitomycin C is an antineoplastic drug, with DNA alkylating activity. It is one of the mitomycin family of compounds, isolated from Streptomyces caespitosus or Streptomyces lavendulae.
(GtoPdb)
DESCRIPTION
DNA crosslinker
(Informer Set)
DESCRIPTION
DNA synthesis inhibitor
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
696
Organisms
7
Compound Sets
20
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
Informer Set
LINCS compound set
NCATS Inxight Approved Drugs
NIH Approved Oncology Drugs
NPC Screening Collection
ReFrame library
Tocris Bioactive Compound Library
Welcome Trust Cancer Drugs
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
56
Molecular Weight
334.13
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
0
cLogP
-1.65
TPSA
146.89
Fraction CSP3
0.53
Chiral centers
4.0
Largest ring
6.0
QED
0.41
Structural alerts
1
quinone_A(370)
[!#6&!#1]=[#6]1[#6]=,:[#6][#6](=[!#6&!#1])[#6]=,:[#6]1
PAINS Family A
Related compounds
Custom attributes
(extracted from source data)
Compound status
FDA
Pathway
DNA replication
DNA Damage/DNA Repair
Target
DNA crosslinker
DNA synthesis
Primary Target
Apoptosis Inducers
MOA
DNA/RNA Synthesis inhibitor
DNA alkylating agent, DNA synthesis inhibitor
Indication
pancreatic cancer, gastric adenocarcinoma
Therapeutic Class
Anticancer Agents
Source data
