General
Preferred name
MG-132
Synonyms
zLLL ()
(S)-MG132 ()
MG 132 ()
Z-Leu-Leu-Leu-al ()
MG132 ()
(S,R,S)-(-)-MG-132, Z-Leu-D-Leu-Leu-al ()
P&D ID
PD003402
CAS
133407-82-6
1211877-36-9
Tags
drug candidate
nuisance
covalent binder
probe
available
Drug indication
Cancer
Probe info
Probe type
calculated probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
34
No orthogonal probes found
Similar probes
1
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Compound 5b is reported to inhibit the enzymatic activity of proteasome macropain .
(GtoPdb)
DESCRIPTION
inhibitor of the proteosome
(Informer Set)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
366
Organisms
2
Compound Sets
19
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Cayman Chemical Bioactives
CovalentInDB
CovBinderInPDB
Drug Repurposing Hub
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Informer Set
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Nuisance compounds in cellular assays
Probe Miner (suitable probes)
Selleckchem Bioactive Compound Library
Welcome Trust Cancer Drugs
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
46
Molecular Weight
475.3
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
14
Ring Count
1
Aromatic Ring Count
1
cLogP
3.59
TPSA
113.6
Fraction CSP3
0.62
Chiral centers
3.0
Largest ring
6.0
QED
0.36
Structural alerts
1
Protein disruption
Proteosome inhibition
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Target
PSMB1
PSMB2
PSMB5
PSMD1
PSMD2
Proteasome
20S proteasome, calpain
Compound status
probe
MOA
Proteasome, Cysteine Protease
Proteasome Inhibitors
Proteasome inhibitor
Member status
virtual
Pathway
Apoptosis
Autophagy
Metabolic Enzyme/Protease
Source data
