General
Preferred name
MG-132
Synonyms
zLLL ()
Z-LLL-al ()
Z-Leu-Leu-Leu-CHO ()
(S)-MG132 ()
MG 132 ()
Z-Leu-Leu-Leu-al ()
(S,R,S)-(-)-MG-132, Z-Leu-D-Leu-Leu-al ()
Z-Leu-Leu-Leu-al, MG132 ()
MG132 ()
MG132 SSS ()
P&D ID
PD003402
CAS
133407-82-6
1211877-36-9
Tags
available
probe
covalent binder
nuisance
drug candidate
Drug indication
Cancer
Probe info
Probe type
calculated probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
34
No orthogonal probes found
Similar probes
1
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Compound 5b is reported to inhibit the enzymatic activity of proteasome macropain .
(GtoPdb)
PRICE
33
DESCRIPTION
inhibitor of the proteosome
(Informer Set)
DESCRIPTION
MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor (IC50=100 nM) that is cell-permeable and reversible. MG-132 acts as an autophagy activator and also induces apoptosis.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
367
Organisms
2
Compound Sets
22
A Collection of Useful Nuisance Compounds (CONS) for Interrogation of Bioassay Integrity
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Cayman Chemical Bioactives
CovalentInDB
CovBinderInPDB
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Informer Set
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Nuisance compounds in cellular assays
Probe Miner (suitable probes)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Welcome Trust Cancer Drugs
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
49
Molecular Weight
475.3
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
14
Ring Count
1
Aromatic Ring Count
1
cLogP
3.59
TPSA
113.6
Fraction CSP3
0.62
Chiral centers
3.0
Largest ring
6.0
QED
0.36
Structural alerts
1
Protein disruption
Proteosome inhibition
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Target
PSMB1
PSMB2
PSMB5
PSMD1
PSMD2
Proteasome
20S proteasome, calpain
Cysteine Protease
20S proteasome
Compound status
probe
MOA
Proteasome, Cysteine Protease
Proteasome Inhibitors
Proteasome inhibitor
Member status
virtual
Pathway
Apoptosis
Autophagy
Proteases/Proteasome
Ubiquitination
Metabolic Enzyme/Protease
Nuisance MOA
Protein disruption
Targets
Proteasome
calpain
autophagy activator
Source data
