General
Preferred name
TG100-115
Synonyms
TG-100-115 ()
TG-100115 ()
TG 100-115 ()
P&D ID
PD003378
CAS
677297-51-7
Tags
available
drug candidate
Drug indication
Angioedema
Myocardial infarction
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION TG-100-115 is an isozyme-selective inhibitor of phosphatidylinositol-3-kinase (PI3K). The discovery and synthesis of this compound is described in , where it is compound 6.
PRICE 92
DESCRIPTION TG100-115 is a PI3K??/?? inhibitor (IC50: 83/235 nM), with fewer effects on PI3K??/??.
DESCRIPTION TG-100-115 is an isozyme-selective inhibitor of phosphatidylinositol-3-kinase (PI3K). The discovery and synthesis of this compound is described in , where it is compound 6. It has subsequently been reported to inhibit the kinase activity of the TRPM7 ion channel, an action that suppresses breast cancer cell migration and invasion . (GtoPdb)
DESCRIPTION inhibitor of PI3K catalytic subunits delta and gamma (Informer Set)
DESCRIPTION TG100-115 is a PI3Kγ/δ inhibitor (IC50: 83/235 nM), with fewer effects on PI3Kα/β. (TargetMol Bioactive Compound Library)
Compound Sets
21
AdooQ Bioactive Compound Library
A10922
Cayman Chemical Bioactives
10010512
ChEMBL Drugs
CHEMBL230011
Clinical kinase drugs
Concise Guide to Pharmacology 2017/18
5715
Concise Guide to Pharmacology 2019/20
5715
Concise Guide to Pharmacology 2021/22
5715
Concise Guide to Pharmacology 2023/24
5715
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB05552
DrugMAP
DMON4IL
EU-OPENSCREEN Bioactive Compound Library
EOS100633
Guide to Pharmacology
5715
Informer Set
606470
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL230011
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
CHEMBL230011
MedChem Express Bioactive Compound Library
HY-10111
ReFrame library
Selleckchem Bioactive Compound Library
TG100-115
TargetMol Bioactive Compound Library
T2672
External IDs
26
Properties
(calculated by RDKit )
Molecular Weight
346.12
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
4
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
4
cLogP
2.33
TPSA
144.06
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.43
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
PIK3CD
PIK3CG
PI3K
PI3Kα
PI3Kβ
PI3Kγ
PI3Kδ
PIK3CA, PIK3CB, PIK3CD, PIK3CG
Compound status
clinical
Targets
PIK3CD,PIK3CG
MOA
PI3K inhibitor
Pathway
PI3K/Akt/mTOR signaling
PI3K/Akt/mTOR
Source data