General
Preferred name
DORAMAPIMOD
Synonyms
BIRB-796 ()
BIRB 0796 ()
BIRB 796 ()
Doramapimod (BIRB-796) ()
BIRB 796 BS ()
BIRB-796 BS ()
Doramapimod (BIRB 796) ()
P&D ID
PD003343
CAS
285983-48-4
1283526-53-3
Tags
available
free of charge
drug candidate
probe
Drug indication
Inflammatory bowel disease
Drug Status
investigational
Max Phase
Phase 2
Probe info
Probe type
experimental probe
Probe sources
Chemical Probes.org
High-quality chemical probes
opnMe Portal
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Doramapimod is an allosteric p38 MAP kinase inhibitor . (GtoPdb)
DESCRIPTION Doramapimod (BIRB 796) is a potent inhibitor of the p38 mitogen activated protein kinase (MAPK). The compound shows anti-inflammatory properties at nanomolar concentrations in cell cultures, which are based on the suppression of TNF-α production. Efficacy of the compound was also shown in animal models of endotoxin-stimulated TNF-α release and collagen-induced arthritis. (opnMe Portal)
MOA Inhibitor (Chemical Probes.org)
DESCRIPTION inhibitor of p38 MAPK (Informer Set)
DESCRIPTION Potent and selective SMYD2 inhibitor (Tocris Bioactive Compound Library)
Cell lines
100
Organisms
0
Compound Sets
26
AdooQ Bioactive Compound Library
A10148
Axon Medchem Screening Library
1358
Cayman Chemical Bioactives
10460
ChEMBL Drugs
CHEMBL103667
Chemical Probes.org
doramapimod
Drug Repurposing Hub
DrugBank
DB03044
DrugMAP
DM6BU7N
EU-OPENSCREEN Bioactive Compound Library
EOS101373
Guide to Pharmacology
5668
High-quality chemical probes
PD003343
Informer Set
660412
Ki Database
BIRB-796
LINCS compound set
10169-101
10169-999
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL103667
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
CHEMBL103667
MedChem Express Bioactive Compound Library
HY-10320
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
opnMe Portal
doramapimod-birb796
PKIDB
ReFrame library
Selleckchem Bioactive Compound Library
BIRB-796-(Doramapimod)
TargetMol Bioactive Compound Library
T6277
Tocris Bioactive Compound Library
5989
Welcome Trust Cancer Drugs
1042
External IDs
34
Properties
(calculated by RDKit )
Molecular Weight
527.29
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
5
Aromatic Ring Count
4
cLogP
5.99
TPSA
80.65
Fraction CSP3
0.35
Chiral centers
0.0
Largest ring
6.0
QED
0.31
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
MAPK11
MAPK14
Androgen receptor (ANDR)
p38??
MAPK11, MAPK12, MAPK13, MAPK14
Raf
MAPK12
MAPK13
JNK,p38 MAPK,Raf,Src
Compound status
probe
Pathway
JNK and p38 signaling
MAPK
Autophagy
MAPK/ERK Pathway
Primary Target
p38 MAPK
MOA
Inhibitor
SAPK2 (p38beta) Inhibitors
Inhibitors of Signal Transduction Pathways
p38 MAPK Inhibitors
p38 MAPK inhibitor
Member status
member
Target class
Kinase
Target subclass
CMGC
Source data