General
Preferred name
IC-87114
Synonyms
IC 87114 ()
IC87114 ()
P&D ID
PD003335
CAS
371242-69-2
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION IC-87114 is a selective inhibitor of PI3Kδ .
Given that PI3Kδ is preferentially expressed in cells of hemopoietic lineage and is involved in neutrophil chemotaxis we have tagged this ligand as having immunopharmacology relevance. Using this chemical tool in in vitro chemotaxis experiments reveals that PI3Kδ activity is required for the directional component of chemotaxis, but is not required for random movement . (GtoPdb)
DESCRIPTION inhibitor of PI3K catalytic subunit delta (Informer Set)
DESCRIPTION IC-87114 is a potent and selective PI3Kδ inhibitor with IC50 of 0.5 μM. (BOC Sciences Bioactive Compounds)
Cell lines
1
Organisms
0
Compound Sets
11
AdooQ Bioactive Compound Library
A10463
Axon Medchem Screening Library
2168
BOC Sciences Bioactive Compounds
ic-87114-cas-371242-69-2-item-84-91217
Cayman Chemical Bioactives
11589
CZ-OPENSCREEN Bioactive Library
DrugMAP
DMM50ED
EU-OPENSCREEN Bioactive Compound Library
EOS100855
Guide to Pharmacology
9376
Informer Set
55307
MedChem Express Bioactive Compound Library
HY-10110
TargetMol Bioactive Compound Library
T2660
External IDs
30
Properties
(calculated by RDKit )
Molecular Weight
397.17
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
5
Aromatic Ring Count
5
cLogP
2.77
TPSA
104.51
Fraction CSP3
0.14
Chiral centers
0.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
PIK3CD
PI3K??
PI3K¦Â
PI3K¦Ã
PI3K¦Ä
PI3K p110d inhibitor
PI3K
Compound status
probe
Pathway
PI3K/Akt/mTOR signaling
PI3K/Akt/mTOR
Source data