General
Preferred name
PF-573228
Synonyms
PF 573228 ()
PF-228 ()
PF573228 ()
P&D ID
PD003320
CAS
869288-64-2
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION PF-573228 is a potent and selective FAK inhibitor with IC50 of 4 nM for purified recombinant catalytic fragment of FAK.
PRICE 71
DESCRIPTION inhibitor of focal adhesion kinase (Informer Set)
DESCRIPTION Potent ABHD6 inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Potent and selective FAK inhibitor (Tocriscreen Plus)
DESCRIPTION PF-573228 is a potent and selective inhibitor of focal adhesion kinase (FAK) (IC50= 4 nM). Displays 50 - 250-fold selectivity for FAK over other protein kinases. PF573228 was recognized to affect cell adhesion and migration in many types of cells. (BOC Sciences Bioactive Compounds)
DESCRIPTION PF-573228 is a potent and selective FAK inhibitor for purified recombinant catalytic fragment of FAK. (Enamine Bioactive Compounds)
DESCRIPTION PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM. (TargetMol Bioactive Compound Library)
Compound Sets
18
AdooQ Bioactive Compound Library
A11235
Axon Medchem Screening Library
1623
BOC Sciences Bioactive Compounds
pf-573228-cas-869288-64-2-item-84-381296
Cayman Chemical Bioactives
14924
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DM32FKD
Enamine Bioactive Compounds
EBC-221075
EU-OPENSCREEN Bioactive Compound Library
EOS100847
Informer Set
660075
LINCS compound set
10199-101
MedChem Express Bioactive Compound Library
HY-10461
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
pf-573228
TargetMol Bioactive Compound Library
T2001
Tocris Bioactive Compound Library
3239
Tocriscreen Plus
3239
ZINC Tool Compounds
ZINC000035636073
External IDs
21
Properties
(calculated by RDKit )
Molecular Weight
491.12
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
3
cLogP
4.14
TPSA
113.08
Fraction CSP3
0.23
Chiral centers
0.0
Largest ring
6.0
QED
0.48
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
PTK2
Apoptosis
FAK
Ligand for Target Protein
CDK1, CDK2, CDK7, GSK3B, IKBKB
FAK inhibitor
Apoptosis related,FAK
Compound status
probe
Target Type
Enzymes
Primary Target
Focal Adhesion Kinase
MOA
Inhibitor
FAK inhbitor
Inhibitor of fibronectin-directed migration
Co-Inducer of apoptosis in pancreatic cancer
focal adhesion kinase inhibitor
Member status
member
Pathway
Protein Tyrosine Kinase/RTK
Angiogenesis
Cytoskeletal Signaling
Tyrosine Kinase/Adaptors
Source data