General
Preferred name
DASA-58
Synonyms
ML203 ()
DASA 58 ()
DASA58 ()
P&D ID
PD003316
CAS
1203494-49-8
Tags
available
probe
Probe info
Probe type
experimental probe
Probe sources
MLP Probes
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION DASA-58 is an activator of tumour-associated pyruvate kinase M2 (PKM2) . PKM2 activation has potential to interfere with the anabolic metabolic pathway that is utilised by cancer cells to maintain high levels of proliferation. Like , DASA-58 promotes formation of highly active PKM2 tetramers and suppresses tumour expansion in vivo . (GtoPdb)
DESCRIPTION Data suggest a therapeutic strategy whereby activation of PKM2 may restore normal cellular metabolism to a state characteristic of normal differentiated cells. The goal of this project was to find pharmacological activators of PKM2 to test this theory. (MLP Probes)
DESCRIPTION activator of muscle pyruvate kinase (PKM2) (Informer Set)
Compound Sets
9
AdooQ Bioactive Compound Library
A15895
Cayman Chemical Bioactives
13941
CZ-OPENSCREEN Bioactive Library
Guide to Pharmacology
10556
Informer Set
411816
MedChem Express Bioactive Compound Library
HY-19330
MLP Probes
NBK56225
Selleckchem Bioactive Compound Library
dasa-58
TargetMol Bioactive Compound Library
T6816
External IDs
21
Properties
(calculated by RDKit )
Molecular Weight
453.1
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
2
cLogP
1.13
TPSA
119.24
Fraction CSP3
0.37
Chiral centers
0.0
Largest ring
7.0
QED
0.69
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
PKM
hPyk-M1
PKM2
pyruvate kinase
Compound status
probe
Antitarget
hPyk-M1, -R, and -L
Pathway
Metabolism
Metabolic Enzyme/Protease
Source data