General
Preferred name
spautin-1
Synonyms
Spautin 1 ()
P&D ID
PD003300
CAS
1262888-28-7
Tags
available
drug candidate
Drug indication
Inflammation
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Spautin-1 is a specific and potent autophagy inhibitor which inhibits ubiquitin-specific peptidases, USP10 and USP13 with IC50s of 0.6-0.7 ¦ÌM.
PRICE 49
DESCRIPTION inhibitor of the deubiquitinase activity of USP13 and USP10 (Informer Set)
DESCRIPTION Potent and selective ATR kinase inhibitor; antitumor (Tocris Bioactive Compound Library)
DESCRIPTION USP10 and USP13 inhibitor; inhibits autophagy (Tocriscreen Plus)
DESCRIPTION Spautin-1 is a potent and specific autophagy inhibitor. Spautin-1 enhances apoptosis. It inhibits cGMP-specific 3',5'-cyclic phosphodiesterase. (Enamine Bioactive Compounds)
DESCRIPTION Spautin-1 is an autophagy inhibitor that suppresses the deubiquitination activity of ubiquitin-specific peptidase USP10 and USP13. Spautin-1 inhibits UPR and exhibits preferential cytotoxicity in glucose-starved cancer cells. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
17
AdooQ Bioactive Compound Library
A12942
Axon Medchem Screening Library
2512
Cayman Chemical Bioactives
17769
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DMJHWYP
Enamine Bioactive Compounds
EBC-07088
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100830
Informer Set
657183
LINCS compound set
10561-101
MedChem Express Bioactive Compound Library
HY-12990
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
spautin-1
TargetMol Bioactive Compound Library
T1937
Tocris Bioactive Compound Library
5197
Tocriscreen Plus
5197
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
271.09
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
3
cLogP
3.52
TPSA
37.81
Fraction CSP3
0.07
Chiral centers
0.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
USP10
USP13
USP10, USP13
USP10-USP13 inhibitor
Deubiquitinase
Apoptosis related,Autophagy,DUB
Compound status
probe
Target Type
Enzymes
Primary Target
Deubiquitinating Enzymes
MOA
Inhibitor
Autophagy agonist
Phosphodiesterase V (PDE5A) Inhibitors
Deubiquitinase inhibitor
Member status
member
Pathway
Apoptosis
Autophagy
Cell Cycle/Checkpoint
DNA Damage/DNA Repair
Ubiquitination
Cell Cycle/DNA Damage
Source data