General
Preferred name
ENZASTAURIN
Synonyms
LY317615 ()
Ly-317615 hydrochloride ()
LY-317615, Enzastaurin HCl ()
LY317615 (Enzastaurin) ()
DB-102 ()
DB102 ()
Kinenza ()
LY-317615 ()
ENZASTAURIN HYDROCHLORIDE ()
Enzastaurin (LY317615) ()
Enzastaurin monohydrochloride ()
Enzastaurin hcl ()
LY317615 HYDROCHLORIDE ()
P&D ID
PD003282
CAS
170364-57-5
359017-79-1
Tags
obsolete probe
nuisance
drug candidate
available
Drug indication
Glioblastoma multiforme
Non-hodgkin lymphoma
Central nervous system disease
Diffuse large B-cell lymphoma
Drug Status
investigational
Max Phase
Phase 3
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Enzastaurin is a selective inhibitor of protein kinase Cβ . Note that reported affinity values may have been generated using the hydrochloride salt (PubChem CID 176166).
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
28
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Cayman Chemical Bioactives
ChEMBL Drugs
Clinical kinase drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugMAP
EUbOPEN Chemogenomics Library
Guide to Pharmacology
Kinase Inhibitors (best-in-class)
LSP-MoA library (Laboratory of Systems Pharmacology)
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Nuisance compounds in cellular assays
Obsolete Compounds
PKIDB
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Welcome Trust Cancer Drugs
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
42
Molecular Weight
515.23
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
7
Aromatic Ring Count
5
cLogP
4.93
TPSA
72.16
Fraction CSP3
0.22
Chiral centers
0.0
Largest ring
6.0
QED
0.34
Structural alerts
2
historic compounds (Chemical Probes.org)
Obsolete
Nonspecific kinase inhibiton
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Target
PKCbeta
PKCβ
PKC??
AKT1, GSK3B, PRKCA, PRKCB, PRKCD, PRKCG
PKC-ß inhibitor
PKC
Known off targets
PKCα, g, ε
Kinase group
AGC
Targets
PRKCB
Pathway
Cytoskeletal Signaling
Apoptosis
Autophagy
Epigenetics
TGF-beta/Smad
Member status
member
MOA
Inhibitors of Signal Transduction Pathways
Protein Kinase PKC beta Inhibitors
Angiogenesis Inhibitors
PKC inhibitor
Therapeutic Class
Anticancer Agents
Source data
