General
Preferred name
GSK650394
Synonyms
GSK 650394 ()
GSK-650394 ()
P&D ID
PD003278
CAS
890842-28-1
Tags
available
drug candidate
Drug indication
Prostate cancer
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
GSK650394 is an inhibitor of the AGC protein kinases SGK1 and SGK2.
(GtoPdb)
DESCRIPTION
GSK 650394 is a novel SGK inhibitor with IC50 of 62 nM and 103 nM for SGK1 and SGK2 in the SPA assay respectively. GSK 650394 also inhibits influenza virus replication.
PRICE
97
DESCRIPTION
Potent and selective PLD1 inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Serum- and glucocorticoid-regulated kinase (SGK) inhibitor
(Tocriscreen Plus)
DESCRIPTION
GSK650394 is a competitive inhibitor that quantitatively blocks the effect of androgens on LNCaP cell growth.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Serum- and glucocorticoid-regulated kinase (SGK) inhibitor
(Tocriscreen Total)
DESCRIPTION
GSK 650394 is an inhibitor of serum- and glucocorticoid-regulated kinases (SGK) that inhibits SGK1 and SGK2 (IC50=62/103 nM). GSK 650394 has antitumor activity and also inhibits osteoclast differentiation and prevents bone loss.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
390
Organisms
0
Compound Sets
19
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
Guide to Pharmacology
Kinase Inhibitors (best-in-class)
LINCS compound set
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
Welcome Trust Cancer Drugs
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
382.17
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
4
cLogP
6.25
TPSA
65.98
Fraction CSP3
0.2
Chiral centers
0.0
Largest ring
6.0
QED
0.44
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Target
SGK3
SGK1/2
Influenza Virus
SGK
SGK1
SGK2
SGK1, SGK2
SGK1 inhibitor
Kinase group
AGC
Primary Target
Other Kinases
MOA
Inhibitor
serum/glucocorticoid regulated kinase inhibitor
Pathway
Metabolic Enzyme/Protease
Metabolism
Microbiology/virology
Anti-infection
Solubility
In Vitro:<br/>DMSO : ≥ 40.7 mg/mL(106.42 mM)<br/>In Vivo:<br/>1.Add each solvent one by one:10% DMSO >> 40%PEG300 >> 5%Tween-804 >> 5% saline<br/>Solubility: 2.5 mg/mL (6.54 mM)
Suspended solution
Need ultrasonic<br/>2.Add each solvent one by one:10% DMSO >> 90% (20%SBE-β-CD in saline)<br/>Solubility: ≥ 2.5 mg/mL (6.54 mM)
Suspended solution<br/>3.Add each solvent one by one:10% DMSO >> 90%corn oil<br/>Solubility: ≥ 2.5 mg/mL (6.54 mM)
Clear solution
Recommended Cell Concentration
None
Source data
