General
Preferred name
ETOPOSIDE
Synonyms
VP-16-213 ()
VP-16 ()
Etoposide (VP-16) ()
Etoposide?(VP-16) ()
VP-16213,Vepesid,VP-16 ()
Toposar ()
VePesid ()
NSC-141540 ()
Etoposide resolution mixture ()
Etoposidum ()
Sintopozid ()
Etoposide-d3 ()
P&D ID
PD003202
CAS
33419-42-0
121471-01-0
Tags
nuisance
natural product
drug
available
Approved by
PMDA
FDA
First approval
1983
Drug Status
approved
Drug indication
Antineoplastic
Solid tumour/cancer
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION A DNA topoisomerase II inhibitor which is a synthetic derivative of podophyllotoxin, found in the American Mayapple (Podophyllum peltatum). (GtoPdb)
DESCRIPTION inhibitor of topoisomerase II (Informer Set)
DESCRIPTION Protein kinase inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Topoisomerase II inhibitor (Tocriscreen Plus)
Cell lines
683
Organisms
3
Compound Sets
33
AdooQ Bioactive Compound Library
A10373
Cayman Chemical Bioactives
12092
26488
ChEMBL Approved Drugs
CHEMBL44657
ChEMBL Drugs
CHEMBL44657
Concise Guide to Pharmacology 2017/18
6815
Concise Guide to Pharmacology 2019/20
6815
Concise Guide to Pharmacology 2021/22
6815
Concise Guide to Pharmacology 2023/24
6815
Drug Repurposing Hub
DrugBank
DB00773
DrugBank Approved Drugs
DB00773
DrugCentral
1112
DrugCentral Approved Drugs
1112
DrugMAP
DMNH3PG
DrugMAP Approved Drugs
DMNH3PG
EU-OPENSCREEN Bioactive Compound Library
EOS100660
Guide to Pharmacology
6815
Informer Set
48589
LINCS compound set
10250-101
10250-999
MedChem Express Bioactive Compound Library
HY-13629
NCATS Inxight Approved Drugs
6PLQ3CP4P3
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Nuisance compounds in cellular assays
Prestwick Chemical Library
Reference compounds for characterizing cellular injury in high-content cellular morphology assays
ReFrame library
Selleckchem Bioactive Compound Library
Etopophos
TargetMol Bioactive Compound Library
T0132
Tocris Bioactive Compound Library
1226
Tocriscreen Plus
1226
Welcome Trust Cancer Drugs
134
External IDs
55
Properties
(calculated by RDKit )
Molecular Weight
588.18
Hydrogen Bond Acceptors
13
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
7
Aromatic Ring Count
2
cLogP
1.34
TPSA
160.83
Fraction CSP3
0.55
Chiral centers
10.0
Largest ring
6.0
QED
0.43
Structural alerts
1
Genotoxic
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Target
TOP2A
TOP2
Topo II
TOP2A, TOP2B
antibiotic
Bacterial
Mitophagy
Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,Autophagy,Mitophagy,Topoisomerase
Compound status
FDA
Target Type
Enzymes
Pathway
DNA replication
DNA Damage/DNA Repair
Anti-infection
Apoptosis
Autophagy
Cell Cycle/DNA Damage
Primary Target
DNA Topoisomerases
MOA
Inhibitor
Topoisomerase
Topoisomerase II inhibitor
Tubulin modulator
"Topoisomerase II inhibitor
Tubulin modulator"
Topoisomerase inhibitor
Member status
member
Indication
non-small cell lung cancer (NSCLC)
Cellular injury category
Genotoxin
Therapeutic Class
Anticancer Agents
Source data