General
Preferred name
CLOBETASOL PROPIONATE
Synonyms
Impoyz ()
CGP9555, CCl 4725 ()
Clobaderm ()
Cormax ()
OLUX ()
Embeline ()
CCI 4725 ()
Dermovate ()
Impeklo ()
Clobex ()
Clobetasol ()
Etrivex ()
Dermovate NN ()
GR-2/925 ()
Dovate ()
CCI-4725 ()
Temovate ()
Clobecort amex ()
Clarelux ()
Temovate E ()
Clobetasol 17-propionate ()
Embeline E ()
NSC-758634 ()
Olux E ()
Psorex ()
GR 2/925 ()
Clobetasol Propionate (Emollient) ()
Clobetasol Propionate ()
Clobetasol Propionate-d5 ()
P&D ID
PD003199
CAS
25122-46-7
2280940-18-1
Tags
available
drug
Approved by
FDA
PMDA
First approval
1985
Drug indication
Plaque psoriasis
psoriasis
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Clobetasol is a highly active, topical corticosteroid. (GtoPdb)
DESCRIPTION Clobetasol propionate is a potent and selective CYP3A5 inhibitor with an IC50 of 0.206 ¦ÌM. Clobetasol propionate has no inhibiting on CYP3A4 or other major CYPs. Clobetasol propionate is a corticosteroid and has the potential for psoriasis and other dermatoses research[1][2][3].
Cell lines
0
Organisms
2
Compound Sets
18
Cayman Chemical Bioactives
21251
33365
ChEMBL Approved Drugs
CHEMBL1159650
ChEMBL Drugs
CHEMBL1159650
Drug Repurposing Hub
DrugBank
DB01013
DrugBank Approved Drugs
DB01013
DrugCentral
4452
DrugCentral Approved Drugs
4452
DrugMAP
DMB1N6P
EU-OPENSCREEN Bioactive Compound Library
EOS101737
Guide to Pharmacology
7062
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1159650
MedChem Express Bioactive Compound Library
HY-13600
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
clobetasol-propionate
External IDs
128
Properties
(calculated by RDKit )
Molecular Weight
466.19
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
0
cLogP
4.1
TPSA
80.67
Fraction CSP3
0.72
Chiral centers
8.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
corticosteroid-responsive dermatoses
Target
NR3C1, PLA2G1B
Glucocorticoid Receptor
Cytochrome P450
MOA
Glucocorticoid Receptor agonist
Pathway
Metabolic Enzyme/Protease
Source data