General
Preferred name
CLOBETASOL PROPIONATE
Synonyms
CGP9555 ()
CCl 4725 ()
Clobetasol 17-propionate ()
Dermovate ()
Temovate ()
Impoyz ()
CGP9555, CCl 4725 ()
Embeline E ()
Impeklo ()
Clobecort amex ()
CCI-4725 ()
Embeline ()
Cormax ()
Clobaderm ()
Temovate E ()
Clarelux ()
Clobetasol Propionate (Emollient) ()
Dermovate NN ()
NSC-758634 ()
Olux E ()
Etrivex ()
Psorex ()
CCI 4725 ()
OLUX ()
Clobex ()
Clobetasol ()
GR 2/925 ()
Dovate ()
Clobetasol Propionate ()
Clobetasol Propionate-d5 ()
P&D ID
PD003199
CAS
25122-46-7
2280940-18-1
Tags
available
drug
Approved by
FDA
PMDA
First approval
1985
Drug indication
Plaque psoriasis
Anti-Inflammatory
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Clobetasol is a highly active, topical corticosteroid. (GtoPdb)
Cell lines
0
Organisms
2
Compound Sets
19
Cayman Chemical Bioactives
21251
33365
ChEMBL Approved Drugs
CHEMBL1159650
ChEMBL Drugs
CHEMBL1159650
Drug Repurposing Hub
DrugBank
DB01013
DrugBank Approved Drugs
DB01013
DrugCentral
4452
DrugCentral Approved Drugs
4452
DrugMAP
DMB1N6P
EU-OPENSCREEN Bioactive Compound Library
EOS101737
Guide to Pharmacology
7062
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1159650
MedChem Express Bioactive Compound Library
HY-13600
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
clobetasol-propionate
TargetMol Bioactive Compound Library
T1561
External IDs
51
Properties
(calculated by RDKit )
Molecular Weight
466.19
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
0
cLogP
4.1
TPSA
80.67
Fraction CSP3
0.72
Chiral centers
8.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Metabolic Enzyme/Protease
Target
Glucocorticoid Receptor
NR3C1, PLA2G1B
Cytochrome P450
Indication
corticosteroid-responsive dermatoses
MOA
Glucocorticoid Receptor agonist
Source data