General
Preferred name
ACITRETIN
Synonyms
Acitretin (sodium) ()
Ro 10-1670 sodium ()
Ro 10-1670 ()
Etretin ()
Etretin, RO 10-1670 ()
Acitretin sodium ()
Ro-101670000 ()
RO 10-1670/000 ()
Soriatane ()
Neotigason ()
RO 10-1670 ()
Acitretin-d3 ()
P&D ID
PD003196
CAS
55079-83-9
54757-46-9
925701-88-8
Tags
natural product
drug
available
Approved by
FDA
First approval
1996
Drug Status
approved
withdrawn
Drug indication
Psoriasis vulgaris
Antipsoriatic
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Acitretin is a second generation retinoid drug. Acitretin is an active metabolite of , but may also be reverse metabolised back to etretinate.
(GtoPdb)
DESCRIPTION
Acitretin sodium is a second-generation, systemic retinoid that has been used in the treatment of psoriasis. It can be considered one of the treatments of choice for pustular and erythrodermic psoriasis. However, the efficacy of acitretin sodium as a monotherapy for plaque psoriasis is less, although it is often used in combination therapy with other systemic psoriasis therapies, especially ultraviolet B or psoralen plus ultraviolet A phototherapy, to increase efficacy. Such combination treatments may potentially minimise toxicity by using lower doses of each of the two agent.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
24
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine BioReference Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
47
Molecular Weight
326.19
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
1
Aromatic Ring Count
1
cLogP
5.17
TPSA
46.53
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.58
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
RAR/RXR
Autophagy
Retinoid Receptor
RAR
RXR
RARA, RARB, RARG, RBP1, RXRA, RXRB, RXRG, STAT3
Pathway
Metabolic Enzyme/Protease
Metabolism
Apoptosis
Vitamin D Related/Nuclear Receptor
MOA
retinoic acid receptor agonist
Retinoid Receptor agonist
Indication
psoriasis
ATC
D05BB02
Toxicity type
reproductive
Therapeutic Class
Keratolytic Agents
Source data
