General
Preferred name
NALTREXONE HYDROCHLORIDE
Synonyms
Naltrexone HCl ()
Depade ()
Trexan ()
Antaxone ()
PTI-901 ()
Nalorex ()
Opizone ()
EN-1639A ()
EN-1639A (AS HYDROCHLORIDE) ()
Adepend ()
ReVia ()
Naltrexone (hydrochloride) ()
P&D ID
PD003195
CAS
16676-29-2
16590-41-3
Tags
natural product
drug
available
Drug Status
approved
Max Phase
Phase 4
First approval
1984
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Potent melatonin agonist (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
10
AdooQ Bioactive Compound Library
A11723
Axon Medchem Screening Library
2416
Cayman Chemical Bioactives
15520
ChEMBL Approved Drugs
CHEMBL1201149
ChEMBL Drugs
CHEMBL1201149
Enamine BioReference Compounds
NIH Clinical Collections (NCC)
Selleckchem Bioactive Compound Library
naltrexone-hcl
TargetMol Bioactive Compound Library
T0963
Tocris Bioactive Compound Library
0677
External IDs
22
Properties
(calculated by RDKit )
Molecular Weight
377.14
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
6
Aromatic Ring Count
1
cLogP
1.95
TPSA
70.0
Fraction CSP3
0.65
Chiral centers
4.0
Largest ring
6.0
QED
0.82
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Endocrinology/Hormones
GPCR/G protein
Neuroscience
Target
Opioid Receptor
Opioid antagonist
Primary Target
Miscellaneous Opioids
MOA
Antagonist
Source data