General
Preferred name
cladribine
Synonyms
2-Chloro-2¡ä-deoxyadenosine ()
2-chlorodeoxyadenosine ()
2-Chloro-2′-deoxyadenosine ()
CldAdo ()
2CdA ()
2-Chloro-2??deoxyadenosine ()
Leustatin ()
Leustatin,2-CdA,2-Chloro-2¡ä-deoxyadenosine,CldAdo,Jk 6251,NSC 105014,RWJ 26251 ()
Cladribine (RWJ 26251) ()
NSC-05014 ()
NSC-105014-F ()
Litak ()
Mavenclad ()
Cladribina ()
Cladaribine ()
RWJ-26251 ()
RWJ 26251 ()
NSC-105014 ()
2-cda ()
Leustat ()
P&D ID
PD003181
CAS
24757-90-2
4291-63-8
Tags
available
prodrug
drug
nuisance
Approved by
FDA
First approval
1993
Drug indication
Multiple sclerosis
Relapsing-remitting multiple sclerosis
Hairy cell leukaemia
Neoplasm
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Cladribine is a purine (adenosine) analogue and an antineoplastic and immunosuppressant agent
(GtoPdb)
PRICE
36
DESCRIPTION
Nrf2 activator
(Tocris Bioactive Compound Library)
DESCRIPTION
Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
28
Organisms
0
Compound Sets
27
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
Nuisance compounds in cellular assays
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
50
Molecular Weight
285.06
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
2
cLogP
-0.3
TPSA
119.31
Fraction CSP3
0.5
Chiral centers
3.0
Largest ring
6.0
QED
0.65
Structural alerts
1
Genotoxic
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Target
Adenosine Deaminase
Adenosine deaminase (MM1.S cells)
Adenosine deaminase (RPMI8226 cells)
Adenosine deaminase (U266 cells)
Apoptosis
ADA, PNP, POLA1, POLE, POLE2, POLE3, POLE4, RRM1, RRM2, RRM2B
Adenosine Deaminase,DNA/RNA Synthesis
Primary Target
Apoptosis Inducers
Member status
virtual
MOA
Antimetabolites
Adenosine Deaminase Inhibitors
"Antimetabolites
Adenosine Deaminase Inhibitors"
adenosine deaminase inhibitor, ribonucleotide reductase inhibitor
Indication
hairy cell leukemia
Biosynthetic Origin
Nucleoside
Therapeutic Indication
Anticancer
Pathway
Metabolism
Therapeutic Class
Anticancer Agents
Source data
