General
Preferred name
cladribine
Synonyms
2-Chloro-2¡ä-deoxyadenosine ()
2CdA ()
CldAdo ()
2-Chloro-2??-deoxyadenosine ()
2-chlorodeoxyadenosine ()
2-Chloro-2??deoxyadenosine ()
Leustatin ()
Cladribine (RWJ 26251) ()
Leustatin,2-CdA,2-Chloro-2¡ä-deoxyadenosine,CldAdo,Jk 6251,NSC 105014,RWJ 26251 ()
RWJ 26251 ()
RWJ-26251 ()
NSC-105014-F ()
NSC-105014 ()
Mavenclad ()
Leustat ()
NSC-05014 ()
Litak ()
2-cda ()
Cladaribine ()
P&D ID
PD003181
CAS
24757-90-2
4291-63-8
Tags
prodrug
nuisance
natural product
drug
available
Approved by
FDA
First approval
1993
Drug Status
investigational
approved
Drug indication
Antineoplastic
Relapsing-remitting multiple sclerosis
Hairy cell leukaemia
Multiple sclerosis
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Cladribine is a purine (adenosine) analogue and an antineoplastic and immunosuppressant agent
(GtoPdb)
DESCRIPTION
Nrf2 activator
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
20
Organisms
0
Compound Sets
27
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
Nuisance compounds in cellular assays
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
47
Molecular Weight
285.06
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
2
cLogP
-0.3
TPSA
119.31
Fraction CSP3
0.5
Chiral centers
3.0
Largest ring
6.0
QED
0.65
Structural alerts
1
Genotoxic
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Pathway
Neuroscience
Target
Adenosine deaminase (MM1.S cells)
Adenosine deaminase (RPMI8226 cells)
Adenosine deaminase (U266 cells)
ADA, PNP, POLA1, POLE, POLE2, POLE3, POLE4, RRM1, RRM2, RRM2B
Adenosine Deaminase,DNA/RNA Synthesis
Primary Target
Apoptosis Inducers
Member status
virtual
MOA
Antimetabolites
Adenosine Deaminase Inhibitors
"Antimetabolites
Adenosine Deaminase Inhibitors"
adenosine deaminase inhibitor, ribonucleotide reductase inhibitor
Indication
hairy cell leukemia
Biosynthetic Origin
Nucleoside
Therapeutic Indication
Anticancer
Therapeutic Class
Anticancer Agents
Source data
