General
Preferred name
didanosine
Synonyms
ddI ()
2',3'-Dideoxyinosine ()
Dideoxyinosine (DDI) ()
NSC-612049 ()
Videx Ec ()
Didanosinum ()
Videx ()
Didanosine system suitability mixture ()
(-)-didanosine ()
BMY-40900 ()
P&D ID
PD003179
CAS
69655-05-6
Tags
prodrug
natural product
drug
available
Approved by
FDA
First approval
1991
Drug Status
approved
Drug indication
Human immunodeficiency virus infection
Antiviral
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Didanosine is an antiretroviral drug.
(GtoPdb)
PHARMACODYNAMICS
Didanosine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Didanosine is a hypoxanthine attached to the sugar ring, unlike other nucleoside analogues. Didanosine is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. Didanosine is effective against HIV, and usually used in combination with other antiviral therapy. Switching from long term AZT treatment to didanosine has been shown to be beneficial. Didanosine has weak acid stability and therefore, it is often combined with an antacid.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
3
Organisms
3
Compound Sets
25
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
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Concise Guide to Pharmacology 2017/18
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Drug Repurposing Hub
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DrugBank Approved Drugs
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DrugCentral Approved Drugs
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DrugMAP Approved Drugs
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[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
54
Molecular Weight
236.09
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
2
cLogP
0.2
TPSA
93.29
Fraction CSP3
0.5
Chiral centers
2.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Microbiology&virology
Anti-infection
Target
Reverse Transcriptase
PNP
HIV
Indication
human immunodeficiency virus (HIV-1)
MOA
nucleoside reverse transcriptase inhibitor
Therapeutic Class
Anti-HIV Agents
Source data
