General
Preferred name
MOCLOBEMIDE
Synonyms
Aurorix ()
Ro111163 ()
4-Chloro-N-(2-morpholin-4-yl-ethyl)-benzamide71320-77-9 ()
Moclobemide (Ro 111163) ()
Ro-111163000 ()
RO 11-1163/000 ()
Manerix ()
GNF-Pf-695 ()
Moclobemide-d4 ()
P&D ID
PD003171
CAS
71320-77-9
108375-13-9
2929883-33-8
Tags
natural product
drug
available
First approval
1990
Drug Status
investigational
approved
Drug indication
Depression
Skin imperfections
Antidepressant
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
ROE
Moclobemide is almost completely renally excreted [L1350]. ;
METABOLISM
Moclobemide is almost completely metabolized in the liver by Cytochrome P450 2C19 and 2D6.; Moclobemide is a substrate of CYP2C19. Although it acts as an inhibitor of CYP1A2, CYP2C19, and CYP2D6 [A3901].
DESCRIPTION
Moclobemide is a reversible inhibitor of monoamine oxidase A (RIMA) . It is an antidepressant and anxiolytic (antianxiety) drug.
(GtoPdb)
DESCRIPTION
Allosteric Akt inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Reversible MAO-A inhibitor
(Tocriscreen Plus)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
30
AdooQ Bioactive Compound Library
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
36
Molecular Weight
268.1
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
1
cLogP
1.4
TPSA
41.57
Fraction CSP3
0.46
Chiral centers
0.0
Largest ring
6.0
QED
0.9
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Pathway
Metabolism
Neuroscience
Neuronal Signaling
Target
MAO-A (5-HT)
MAOA, MAOB
Monoamine Oxidase
MAO
Primary Target
Monoamine Oxidases
MOA
Inhibitor
MAO-A Inhibitors
monoamine oxidase inhibitor
Member status
member
Indication
depression, anxiety
Therapeutic Class
Antidepressants
Source data
