General
Preferred name
AMINOLEVULINIC ACID
Synonyms
AMINOLEVULINIC ACID HYDROCHLORIDE ()
Pentanoic acid, 5-amino-4-oxo- ()
DELTA-AMINOLEVULINIC ACID ()
ALA ()
Hydrangin ()
5-ALA ()
5-Aminolevulinic acid HCl ()
ALA hydrochloride ()
Levulan ()
Aminolevulinic acid hci ()
5-Aminolevulinic acid (hydrochloride) ()
5-aminolevulinic acid ()
5-ALA (hydrochloride) ()
δ-Aminolevulinic acid (hydrochloride) ()
5-Amino-4-oxopentanoic acid (hydrochloride) ()
δ-Aminolevulinic acid ()
5-Amino-4-oxopentanoic acid ()
5-ALA hydrochloride ()
5-Aminolevulinic acid hydrochloride ()
Aminolevulinic acid hydrochlorideLevulanAminolevulinic acid5-Aminolevulinate hydrochloride.delta.-Aminolevulinic acid hydrochloridePentanoic acid, 5-amino-4-oxo-, hydrochlorideLevulinic acid, 5-amino-, hydrochloride ()
Alaglio ()
Gleolan ()
Ameluz ()
Aminolevulinic acid hcl ()
5 ala hcl (trivial name) ()
Alabel ()
NSC-18509 ()
Gliolan ()
NPC-07 ()
.delta.-Aminolevulinic acid hydrochloride ()
¦Ä-Aminolevulinic acid (hydrochloride) ()
.delta.-aminolevulinic acid ()
¦Ä-Aminolevulinic acid ()
P&D ID
PD003147
CAS
5451-09-2
106-60-5
Tags
available
prodrug
covalent binder
drug
Approved by
FDA
First approval
1999
Drug indication
Acne vulgaris
Actinic keratosis
acne
Glioblastoma multiforme
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION 5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.
PRICE 29
DESCRIPTION Approved as aminolevulinic acid (GtoPdb)
DESCRIPTION 5-Aminolevulinic acid (5-ALA) is a non-protein amino acid that plays a rate-limiting role in heme biosynthesis.
DESCRIPTION Aminolevulinic acid is a porphyrin precursor used to treat actinic keratosis of the face, scalp, and upper extremities, as well as to visualize a glioma. (Enamine Bioactive Compounds)
DESCRIPTION 5-Aminolevulinic acid hydrochloride (5-ALA) is an intermediate in heme biosynthesis and a universal precursor of tetrapyrroles. (TargetMol Bioactive Compound Library)
Cell lines
3
Organisms
0
Compound Sets
29
AdooQ Bioactive Compound Library
A10016
Cayman Chemical Bioactives
9001902
ChEMBL Approved Drugs
CHEMBL1200582
CHEMBL601
ChEMBL Drugs
CHEMBL1200582
CHEMBL601
Concise Guide to Pharmacology 2017/18
4784
Concise Guide to Pharmacology 2019/20
4784
Concise Guide to Pharmacology 2021/22
4784
Concise Guide to Pharmacology 2023/24
4784
CovBinderInPDB
CBR001247
CBR004392
CBR005760
Drug Repurposing Hub
DrugBank
DB00855
DrugBank Approved Drugs
DB00855
DrugCentral
166
DrugCentral Approved Drugs
166
DrugMAP
DMWNHPC
DMS4BLQ
DrugMAP Approved Drugs
DMWNHPC
DMS4BLQ
DrugMatrix
Enamine Bioactive Compounds
EBC-17028
Guide to Pharmacology
4784
MedChem Express Bioactive Compound Library
HY-N0305
HY-W000450
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
88755TAZ87
NIH Approved Oncology Drugs
541468
NIH Clinical Collections (NCC)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
5-Aminolevulinic-acid-hydrochloride
TargetMol Bioactive Compound Library
T1662
The Spectrum Collection
External IDs
87
Properties
(calculated by RDKit )
Molecular Weight
131.06
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.62
TPSA
80.39
Fraction CSP3
0.6
Chiral centers
0.0
Largest ring
0.0
QED
0.53
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Autophagy
Mitophagy
oxidizing agent
Indication
glioma, actinic keratosis (AK)
Disease Area
oncology, dermatology
Target
ALAD
Endogenous Metabolite
Pathway
Apoptosis
Metabolism
Metabolic Enzyme/Protease
Biosynthetic Origin
Other (Amino Acid)
Therapeutic Indication
Anticancer
Source data