General
Preferred name
AMOXICILLIN
Synonyms
Amoxycillin trihydrate ()
Amoxil trihydrate ()
Amoxipen trihydrate ()
Moxaline trihydrate ()
Amoxycillin ()
AMOXICILLIN ANHYDROUS ()
Amoxicillin sesquihydrate ()
Amoxicillin (sodium) ()
Amoxicillin (trihydrate) ()
Amoxycillin (sodium) ()
Amoxycillin (trihydrate) ()
Clavulanate,Amoxycillin sodium ()
Amoxil trihydrate, Amoxipen trihydrate, Moxaline trihydrate ()
AMOXICILLIN SODIUM ()
Amoxicillin trihydrate ()
Amoxicillin (hydrate) ()
Biomox ()
Amoxicillin component of talicia ()
Amoxil Fiztab ()
Robamox ()
Zoxycil 250 ()
Amoxicillin component of clavulox trihydrate ()
Respillin ()
Amoxicillin component of augmentin ()
Amoxicillin (as trihydrate) ()
Amix 125 ()
Amix 500 ()
Trimox ()
Amoxicillin component of prevpac ()
Demoksil ()
Amoxicillin hydrate ()
Polymox ()
Amoxil ()
Sumox ()
Amoxident 500 ()
Remoxil ()
Amoxil SF ()
Amoxicillin Pediatric ()
Aquacil ()
Wymox ()
Damoxy ()
BRL-2333 ()
Atoksilin ()
Dispermox ()
Galenamox ()
Dedoxil ()
Zoxycil 500 ()
Amoram ()
Moksilin ()
Amrit ()
Amoxicillinum trihydricum ()
Amopen ()
Amoxicilline ()
Largopen ()
Vetremox ()
Amoxicillin (anhydrous) ()
Amoxyke ()
Amoxident 250 ()
Amoxicilina ()
Flemoxin Solutab ()
Topramoxin ()
Larotid ()
Promoxil ()
BRL 2333 ()
NSC-277174 ()
Moxatag ()
Amoxi-Inject ()
Utimox ()
Amoxi-Tabs ()
Amoxymed ()
Amix 250 ()
Amoxicillin (as the sodium salt) ()
Sodium amoxicillin ()
Amoxicillin sodium salt ()
Amoxycillin (as sodium) ()
BRL-2333AB-B ()
Amoxicillin-d4 ()
P&D ID
PD003145
CAS
61336-70-7
26787-78-0
34642-77-8
2673270-36-3
Tags
available
covalent binder
drug
drug candidate
Approved by
FDA
First approval
1974
Drug indication
infection
Duodenal ulcer
Bacterial infection
Drug Status
vet_approved
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Amoxicillin is a widely used penicillin class antibacterial. (GtoPdb)
PHARMACODYNAMICS Amoxicillin is a moderate-spectrum antibiotic active against a wide range of Gram-positive, and a limited range of Gram-negative organisms. Compared to its peers within the class of beta-lactam antibiotics, amoxicillin is often selected for use because it tends to demonstrate better absorption after oral administration. Amoxicillin is susceptible to degradation by β-lactamase-producing bacteria, and so may be given with clavulanic acid to increase its susceptability. The incidence of β-lactamase-producing resistant organisms, including E. coli, appears to be increasing. Amoxicillin is sometimes combined with clavulanic acid, a β-lactamase inhibitor, to increase the spectrum of action against Gram-negative organisms, and to overcome bacterial antibiotic resistance mediated through β-lactamase production.
PRICE 29
DESCRIPTION Amoxicillin (Amoxycillin) is an antibiotic with good oral absorption and broad spectrum antimicrobial activity. Amoxicillin inhibits the biosynthesis of polypeptides in the cell wall, thereby inhibiting cell growth[1][2][3].
PRICE 29
DESCRIPTION Amoxicillin (Amoxycillin) sodium is an antibiotic with good oral absorption and broad spectrum antimicrobial activity. Amoxicillin sodium inhibits the biosynthesis of polypeptides in the cell wall, thereby inhibiting cell growth[1][2][3].
DESCRIPTION Amoxicillin Sodium (Clavulanate) is a moderate- spectrum, bacteriolytic, ??-lactam antibiotic.
DESCRIPTION Amoxicillin (Amoxycillin) trihydrateis an antibiotic with good oral absorption and broad spectrum antimicrobial activity. Amoxicillin trihydrateis inhibits the biosynthesis of polypeptides in the cell wall, thereby inhibiting cell growth[1][2][3].
DESCRIPTION Amoxicillin is a penicillin derivative used for the treatment of infections caused by gram-positive bacteria, in particular streptococcal bacteria causing upper respiratory tract infections. (Enamine Bioactive Compounds)
DESCRIPTION Amoxicillin trihydrate (Moxaline trihydrate) binds to and inactivates penicillin-binding protein (PBP) 1A located on the inner membrane of the bacterial cell wall. Amoxicillin trihydrate is a broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis. (TargetMol Bioactive Compound Library)
DESCRIPTION Amoxicillin (Amoxycillin) binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Amoxicillin Anhydrous is the anhydrous form of a broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis. (TargetMol Bioactive Compound Library)
DESCRIPTION Amoxicillin Sodium (Clavulanate) is a moderate- spectrum, bacteriolytic, β-lactam antibiotic. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
2
Compound Sets
22
Cayman Chemical Bioactives
19188
25428
ChEMBL Approved Drugs
CHEMBL1082
ChEMBL Drugs
CHEMBL1082
CHEMBL2105950
CovBinderInPDB
CBR002134
CBR003140
CBR004025
Drug Repurposing Hub
DrugBank
DB01060
DrugBank Approved Drugs
DB01060
DrugCentral
192
DrugCentral Approved Drugs
192
DrugMAP
DMUYNEI
DrugMAP Approved Drugs
DMUYNEI
Enamine Bioactive Compounds
EBC-15035
Enamine BioReference Compounds
Guide to Pharmacology
10895
MedChem Express Bioactive Compound Library
HY-B0467A
HY-B0467
HY-B0467B
NCATS Inxight Approved Drugs
9EM05410Q9
NIH Clinical Collections (NCC)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
amoxicillin-trihydrate
amoxicillin-amoxycillin
amoxicillin-amox
TargetMol Bioactive Compound Library
T1005L
T1005
T6385
External IDs
108
Properties
(calculated by RDKit )
Molecular Weight
365.1
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
4
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
1
cLogP
0.02
TPSA
132.96
Fraction CSP3
0.44
Chiral centers
4.0
Largest ring
6.0
QED
0.55
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
Bacterial
PBPs
CYP2C19, SLC15A1, SLC15A2, SLC22A6
Antibiotics,Bacterial
Indication
skin infections, duodenal ulcer disease, gonorrhea, ear infections, throat infections, genitourinary tract infections, respiratory tract infections
Disease Area
infectious disease, gastroenterology
MOA
penicillin binding protein inhibitor
Pathway
Microbiology/virology
Anti-infection
Therapeutic Class
Antibiotics
Source data