General
Preferred name
AMOXICILLIN
Synonyms
Amoxycillin trihydrate ()
Amoxycillin ()
Amoxil trihydrate ()
Amoxipen trihydrate ()
Moxaline trihydrate ()
AMOXICILLIN ANHYDROUS ()
Amoxicillin sesquihydrate ()
Amoxycillin (sodium) ()
Amoxycillin (trihydrate) ()
Amoxicillin (sodium) ()
Amoxicillin (trihydrate) ()
AMOXICILLIN SODIUM ()
Amoxicillin trihydrate ()
Clavulanate,Amoxycillin sodium ()
Amoxil trihydrate, Amoxipen trihydrate, Moxaline trihydrate ()
Biomox ()
Amoxicilina ()
Amoxicilline ()
Amoxident 500 ()
Utimox ()
Damoxy ()
Amoxicillin (anhydrous) ()
Zoxycil 500 ()
Amix 250 ()
Atoksilin ()
Amoxil SF ()
Amix 500 ()
Amoxi-Inject ()
Aquacil ()
Amopen ()
Amoxi-Tabs ()
Respillin ()
Amrit ()
Amoxicillin hydrate ()
Amoxymed ()
Amoxicillin Pediatric ()
Moxatag ()
Amoxicillinum trihydricum ()
Remoxil ()
Amix 125 ()
Amoxicillin (as trihydrate) ()
Amoxyke ()
Dispermox ()
Amoram ()
Amoxident 250 ()
Polymox ()
Galenamox ()
Moksilin ()
Sumox ()
Amoxil ()
Larotid ()
Zoxycil 250 ()
Vetremox ()
NSC-277174 ()
BRL-2333 ()
Promoxil ()
Dedoxil ()
BRL 2333 ()
Robamox ()
Wymox ()
Flemoxin Solutab ()
Largopen ()
Trimox ()
Demoksil ()
Topramoxin ()
Amoxil Fiztab ()
Amoxicillin sodium salt ()
Amoxicillin (as the sodium salt) ()
BRL-2333AB-B ()
Amoxycillin (as sodium) ()
Sodium amoxicillin ()
Amoxicillin (hydrate) ()
Amoxicillin-d4 ()
P&D ID
PD003145
CAS
26787-78-0
61336-70-7
34642-77-8
2673270-36-3
Tags
available
covalent binder
drug
Approved by
FDA
First approval
1974
Drug indication
Bacterial infection
Antibacterial
Drug Status
approved
vet_approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Amoxicillin is a widely used penicillin class antibacterial. (GtoPdb)
PHARMACODYNAMICS Amoxicillin is a moderate-spectrum antibiotic active against a wide range of Gram-positive, and a limited range of Gram-negative organisms. Compared to its peers within the class of beta-lactam antibiotics, amoxicillin is often selected for use because it tends to demonstrate better absorption after oral administration. Amoxicillin is susceptible to degradation by β-lactamase-producing bacteria, and so may be given with clavulanic acid to increase its susceptability. The incidence of β-lactamase-producing resistant organisms, including E. coli, appears to be increasing. Amoxicillin is sometimes combined with clavulanic acid, a β-lactamase inhibitor, to increase the spectrum of action against Gram-negative organisms, and to overcome bacterial antibiotic resistance mediated through β-lactamase production.
Cell lines
1
Organisms
2
Compound Sets
21
Cayman Chemical Bioactives
19188
25428
ChEMBL Approved Drugs
CHEMBL1082
CHEMBL2105950
ChEMBL Drugs
CHEMBL1082
CHEMBL2105950
CovBinderInPDB
CBR002134
CBR003140
CBR004025
Drug Repurposing Hub
DrugBank
DB01060
DrugBank Approved Drugs
DB01060
DrugCentral
192
DrugCentral Approved Drugs
192
DrugMAP
DMUYNEI
DrugMAP Approved Drugs
DMUYNEI
Enamine BioReference Compounds
Guide to Pharmacology
10895
MedChem Express Bioactive Compound Library
HY-B0467A
HY-B0467
HY-B0467B
NCATS Inxight Approved Drugs
9EM05410Q9
NIH Clinical Collections (NCC)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
amoxicillin-trihydrate
amoxicillin-amoxycillin
amoxicillin-amox
TargetMol Bioactive Compound Library
T1005
External IDs
108
Properties
(calculated by RDKit )
Molecular Weight
365.1
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
4
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
1
cLogP
0.02
TPSA
132.96
Fraction CSP3
0.44
Chiral centers
4.0
Largest ring
6.0
QED
0.55
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Microbiology/virology
Anti-infection
Target
antibiotic
CYP2C19, SLC15A1, SLC15A2, SLC22A6
Bacterial
Antibiotics,Bacterial
Indication
skin infections, duodenal ulcer disease, gonorrhea, ear infections, throat infections, genitourinary tract infections, respiratory tract infections
Disease Area
infectious disease, gastroenterology
MOA
penicillin binding protein inhibitor
Therapeutic Class
Antibiotics
Source data