General
Preferred name
UBENIMEX
Synonyms
BESTATIN HYDROCHLORIDE ()
bestatin ()
Ubenimex trifluoroacetate ()
Bestatin (trifluoroacetate) ()
Ubenimex hydrochloride ()
BESTATIN58970-76-6 ()
Bestatin (hydrochloride) ()
Ubenimex,NK421 ()
Bestatin trifluoroacetate ()
Bestatin (NK421) ()
Bestatin ()
NSC-265489 ()
(-)-bestatin ()
NK-421 ()
P&D ID
PD003128
CAS
58970-76-6
100992-60-7
65391-42-6
223763-80-2
Tags
available
drug
Drug indication
Acute myeloid leukaemia
Pulmonary arterial hypertension
Drug Status
approved
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor. Bestatin has anticancer effects[1][2].
PRICE
51
DESCRIPTION
Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.
PRICE
54
DESCRIPTION
Potent, selective p38 MAPK inhibitor; orally active
(Tocris Bioactive Compound Library)
DESCRIPTION
Aminopeptidase inhibitor
(Tocriscreen Total)
DESCRIPTION
Bestatin is a competitive protease inhibitor. It is an inhibitor of cytosol aminopeptidase (Ki= 0.4 nM), aminopeptidase B (Ki= 14 nM), leukotriene A4 hydrolase ( Km = 0.17 µM), aminopeptidase N (Km = 14 nM). It is being studied for use in the treatment of acute myelocytic leukemia.
(Enamine Bioactive Compounds)
DESCRIPTION
Bestatin (Ubenimex) competitively inhibits many aminopeptidases, including B, N and leucine aminopeptidases. Ubenimex is a microbial metabolite and dipeptide with potential immunomodulatory and antitumor activities. Aminopeptidases has been implicated in the process of cell adhesion and invasion of tumor cells. Therefore, inhibiting aminopeptidases may partially attribute to the antitumor effect of ubenimex. This agent also activates T lymphocyte, macrophage, and bone marrow stem cell as well as stimulates the release of interleukin-1 and -2, thus further enhances its antitumor activity.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Aminopeptidase inhibitor
(LOPAC library)
DESCRIPTION
Bestatin hydrochloride (Ubenimex hydrochloride) is an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Bestatin, also known as Ubenimex (INN), is a competitive protease inhibitor. It is an inhibitor of aminopeptidase B, leukotriene A4 hydrolase, aminopeptidase N. It is being studied for use in the treatment of acute myelocytic leukemia.
Bestatin can be administered, with low toxicity, to cultured cells, intact animals and humans. It has become a useful tool in elucidating the physiological role of some mammalian exopeptidases in the regulation of the immune system, in the growth of tumors and their invasion of surrounding tissues, and in the degradation of cellular proteins. (BOC Sciences Bioactive Compounds)
Bestatin can be administered, with low toxicity, to cultured cells, intact animals and humans. It has become a useful tool in elucidating the physiological role of some mammalian exopeptidases in the regulation of the immune system, in the growth of tumors and their invasion of surrounding tissues, and in the degradation of cellular proteins. (BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
8
Organisms
1
Compound Sets
24
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
EU-OPENSCREEN Bioactive Compound Library
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
58
Molecular Weight
308.17
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
4
Rotatable Bonds
8
Ring Count
1
Aromatic Ring Count
1
cLogP
0.53
TPSA
112.65
Fraction CSP3
0.5
Chiral centers
3.0
Largest ring
6.0
QED
0.56
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Aminopeptidase
Pathway
Metabolic Enzyme/Protease
Immunology/Inflammation
Metabolism
Microbiology/virology
Cytoskeletal Signaling
Anti-infection
Target
antibiotic
APN
Bacterial
LTA(4)H-h
CD13
LTA4H, RNPEP
Immunology & Inflammation related
Primary Target
Aminopeptidases
MOA
LTR inhibitor
Others inhibitor
Inhibitor
Leukotriene A4 Hydrolase Inhibitors
Membrane Alanine Aminopeptidase (Aminopeptidase N) Inhibitors
leukotriene synthesis inhibitor
Member status
member
Indication
acute myeloid leukemia (AML)
Source data
