General
Preferred name
LEVOCETIRIZINE
Synonyms
LEVOCETIRIZINE DIHYDROCHLORIDE ()
Xyzal Dihydrochloride ()
(-)-Cetirizine Dihydrochloride ()
Levocetirizine HCl ()
Levocetirizine (dihydrochloride) ()
(R)-Cetirizine (dihydrochloride) ()
Xyzal Dihydrochloride, (-)-Cetirizine Dihydrochloride ()
LCZ, (R)-Cetirizine ()
(R)-Cetirizine (hydrochloride) ()
Cetirizine hydrochloride (r)- ()
Levocetirizine hydrochloride ()
UCB 28556 ()
UCB-28556 ()
Levocetirizine monohydrochloride ()
Xyzal allergy 24hr ()
Xusal ()
Xyzal ()
Xyzall ()
Cetirizine (r)-form dihydrochloride ()
NSC-758898 ()
(R)-cetirizine ()
Cetirizine, (-)- ()
Cetirizine, (r)- ()
(-)-cetirizine ()
Xazal ()
Levocetirizina ()
Cetirizine (r)-form ()
(R)-Cetirizine ()
P&D ID
PD003122
CAS
130018-77-8
130018-87-0
Tags
available
drug
Approved by
FDA
First approval
2007
Drug indication
Allergy
Fish-eye disease
Allergic rhinitis
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Levocetirizine dihydrochloride ((R)-Cetirizine dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Levocetirizine dihydrochloride is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine dihydrochloride has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[1].
PRICE
35
DESCRIPTION
Levocetirizine is an antihistamine, and is a component of the approved drug , but this enantiomer is approved in its own right.
(GtoPdb)
DESCRIPTION
Levocetirizine ((R)-Cetirizine) is a third-generation peripheral H1-receptor antagonist. Levocetirizine is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[1].
PRICE
45
DESCRIPTION
Levocetirizine Dihydrochloride (Xyzal Dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Acting as an antihistaminic agent, it specifically targets the histamine H1-receptor. Levocetirizine Dihydrochloride is the R-enantiomer of Cetirizine, which gives it a higher affinity for the H1-receptor than the S-enantiomer. Due to this enhanced affinity, Levocetirizine Dihydrochloride is effective in treating allergic rhinitis and chronic idiopathic urticaria.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Levocetirizine is a Histamine-1 Receptor Antagonist. The mechanism of action of levocetirizine is as a Histamine H1 Receptor Antagonist.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
19
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Selleckchem Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
60
Molecular Weight
388.16
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
8
Ring Count
3
Aromatic Ring Count
2
cLogP
3.15
TPSA
53.01
Fraction CSP3
0.38
Chiral centers
1.0
Largest ring
6.0
QED
0.7
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Neuronal Signaling
Indication
allergic rhinitis, urticaria
Target
HRH1
Histamine Receptor
H1 receptor
MOA
Histamine Receptor antagonist
Therapeutic Class
Antiallergic Agents
Source data
