General
Preferred name
LEVOCETIRIZINE
Synonyms
LEVOCETIRIZINE DIHYDROCHLORIDE ()
Levocetirizine HCl ()
Levocetirizine (dihydrochloride) ()
(R)-Cetirizine ()
(R)-Cetirizine (dihydrochloride) ()
Xyzal Dihydrochloride, (-)-Cetirizine Dihydrochloride ()
LCZ, (R)-Cetirizine ()
Cetirizine (r)-form dihydrochloride ()
Xusal ()
NSC-758898 ()
Levocetirizine monohydrochloride ()
UCB 28556 ()
Cetirizine hydrochloride (r)- ()
Xyzall ()
Xyzal ()
Xyzal allergy 24hr ()
UCB-28556 ()
Levocetirizine hydrochloride ()
(R)-cetirizine ()
Cetirizine, (-)- ()
Xazal ()
Cetirizine (r)-form ()
Cetirizine, (r)- ()
(-)-cetirizine ()
(R)-Cetirizine (hydrochloride) ()
P&D ID
PD003122
CAS
130018-77-8
130018-87-0
Tags
natural product
drug
available
Approved by
FDA
First approval
2007
Drug Status
approved
Drug indication
Allergy
Allergic rhinitis
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Levocetirizine is an antihistamine, and is a component of the approved drug , but this enantiomer is approved in its own right. (GtoPdb)
Compound Sets
19
Cayman Chemical Bioactives
23992
ChEMBL Approved Drugs
CHEMBL1201190
CHEMBL1201191
ChEMBL Drugs
CHEMBL1201190
CHEMBL1201191
Drug Repurposing Hub
DrugBank
DB06282
DrugBank Approved Drugs
DB06282
DrugCentral
1566
DrugCentral Approved Drugs
1566
DrugMAP
DMW6ZJI
DMQYLGP
DrugMAP Approved Drugs
DMW6ZJI
DMQYLGP
Guide to Pharmacology
1214
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1201190
MedChem Express Bioactive Compound Library
HY-W010841
HY-B0814
NCATS Inxight Approved Drugs
6U5EA9RT2O
NIH Clinical Collections (NCC)
NPC Screening Collection
Selleckchem Bioactive Compound Library
levocetirizine-dihydrochloride
levocetirizine
TargetMol Bioactive Compound Library
T1469
The Spectrum Collection
External IDs
57
Properties
(calculated by RDKit )
Molecular Weight
388.16
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
8
Ring Count
3
Aromatic Ring Count
2
cLogP
3.15
TPSA
53.01
Fraction CSP3
0.38
Chiral centers
1.0
Largest ring
6.0
QED
0.7
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Neuronal Signaling
Target
H1 receptor
HRH1
Histamine Receptor
Indication
allergic rhinitis, urticaria
MOA
Histamine Receptor antagonist
Therapeutic Class
Antiallergic Agents
Source data