General
Preferred name
LEVONORGESTREL
Synonyms
NORGESTREL ()
SH-850 ()
FH 122-A ()
WY-3707 ()
SH-70850 ()
D-Norgestrel ()
Norgestrel-(-)-D ()
Preven-levonorgestrel ()
(-) - Norgestrel ()
WY-3707, SH-70850, SH-850, FH 122-A ()
Levonorgestrel-d6 ()
Levonorgestrel component of quasense ()
Levonorgestrel component of orsythia ()
Levosert ()
Levonorgestrel component of myzilra ()
Isteranda ()
WY-5104 ()
Levonorgestrel component of nordette ()
Levonorgestrel component of setlakin ()
Norgestrel, (-)- ()
Postinor-2 ()
Levonorgestrel component of introvale ()
Levonorgestrel component of aviane ()
Kyleena ()
Levonorgestrel component of marlissa ()
Levonorgestrel component of levora ()
Levonorgestrel component of triphasil ()
Levonorgestrel component of alesse ()
Levonorgestrel component of quartette ()
Liletta ()
NSC-744007 ()
Jadelle ()
Levonelle One Step ()
Plan B ()
Levonorgestrel component of balcoltra ()
Norplant ()
Plan B One-Step ()
Levonorgestrel component of kyleena ()
Mirena ()
Levonorgestrel component of tyblume ()
Levonorgestrel component of seasonale ()
Levonorgestrel component of levlite ()
Athentia next ()
Levonelle-2 ()
Levonorgestrel component of levonest ()
Jaydess ()
Norplant Ii ()
Levonorgestrel component of altavera ()
Levonorgestrel component of climara pro ()
Levonorgestrel component of opcicon one-step ()
Levonorgestrel component of vienva ()
Levonorgestrel component of lybrel ()
Opcicon one-step ()
Ezinelle ()
Microval ()
Levonorgestrel component of elifemme ()
Levonorgestrel component of lessina ()
Fallback solo ()
Levonelle ()
Levonorgestrel component of seasonique ()
Levonorgestrel component of trivora ()
Levonorgestrel component of afirmelle ()
Her style ()
Levonorgestrel component of twirla ()
Norgeston ()
Skyla ()
BAY86-5028 ()
Levonorgestrel component of loseasonique ()
Levonorgestrel component of preven ()
Upostelle ()
Levonorgestrelum ()
Emerres ()
Emerres Una ()
Levonorgestrel component of enpresse ()
Levonorgestrel component of portia ()
Levonorgestrel component of kurvelo ()
Norgestrel (-)-form ()
Norgestrel-d6 ()
P&D ID
PD003121
CAS
797-63-7
121714-72-5
6533-00-2
2376035-98-0
Tags
available
drug
Approved by
PMDA
FDA
First approval
1982
1968
Drug indication
Endometriosis
Contraception
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Levonorgestrel is the name for the active isomer in norgestrel, a racemic mixture (GtoPdb)
DESCRIPTION Levonorgestrel is an orally active inhibitor of progesterone (HY-N0437). Levonorgestrel has anticancer activity and can induce Apoptosis. Levonorgestrel can be used as a contraceptive and in combination with other medications. Levonorgestrel can be used in the study of osteoporosis and uterine leiomyoma[1][2][3][4][5].
DESCRIPTION Norgestrel is a synthetic analog of progesterone, a compound commonly found in oral contraceptive pill, and a powerful neuroprotective antioxidant, preventing light-induced ROS in photoreceptor cells, and cell death[1][2]. Norgestrel is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
PRICE 29
DESCRIPTION Selective RORgamma inverse agonist (Tocris Bioactive Compound Library)
DESCRIPTION Synthetic progesterone analog (Tocriscreen Plus)
DESCRIPTION Levonorgestrel is a synthetic progestogen similar to Progesterone. It is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device. (Enamine Bioactive Compounds)
DESCRIPTION Norgestrel (WY-3707) is a synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel suppresses the secretion of luteinizing and follicle-stimulating hormones (LH and FSH), thickens cervical mucus, and slows the transit of ova through the fallopian tubes. (TargetMol Bioactive Compound Library)
DESCRIPTION Levonorgestrel (D-Norgestrel) is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization. (TargetMol Bioactive Compound Library)
Compound Sets
32
AdooQ Bioactive Compound Library
A10529
Axon Medchem Screening Library
2065
Cayman Chemical Bioactives
10006318
25231
28477
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1389
ChEMBL Drugs
CHEMBL1389
Concise Guide to Pharmacology 2017/18
2881
Concise Guide to Pharmacology 2019/20
2881
Concise Guide to Pharmacology 2021/22
2881
Concise Guide to Pharmacology 2023/24
2881
Drug Repurposing Hub
DrugBank
DB00367
DrugBank Approved Drugs
DB00367
DrugCentral
1572
DrugCentral Approved Drugs
1572
DrugMAP
DM1DP7T
DrugMAP Approved Drugs
DM1DP7T
Enamine Bioactive Compounds
EBC-11102
Enamine BioReference Compounds
Guide to Pharmacology
2881
MedChem Express Bioactive Compound Library
HY-B0257
HY-N7137
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
5W7SIA7YZW
NIH Clinical Collections (NCC)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Levonorgestrel(Levonelle)
norgestrel
TargetMol Bioactive Compound Library
T1263
T2597
Tocris Bioactive Compound Library
4833
Tocriscreen Plus
4833
External IDs
65
Properties
(calculated by RDKit )
Molecular Weight
312.21
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
4
Aromatic Ring Count
0
cLogP
3.88
TPSA
37.3
Fraction CSP3
0.76
Chiral centers
6.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Nuclear Receptors
MOA
Progesterone receptor agonist
Agonist
estrogen receptor agonist, glucocorticoid receptor antagonist, progesterone receptor agonist, progesterone receptor antagonist
Target
Progesterone Receptor
ER
Reactive Oxygen Species
SRD5A1
AR, ESR1, PGR, SRD5A1
PGR
PR agonist
Apoptosis
Bcl-2 Family
Caspase
Survivin
Reactive Oxygen Species (ROS)
Estrogen/progestogen Receptor
ROS
Primary Target
Progesterone Receptors
Indication
contraceptive
Biosynthetic Origin
Terpenoid (Steroid)
Therapeutic Indication
Contraception
Therapeutic Class
Hormone Therapy
Contraceptive Agents
Pathway
Immunology/Inflammation
Metabolic Enzyme/Protease
NF-κB
Endocrinology/Hormones
Metabolism
NF-¦ÊB
Source data