General
Preferred name
medroxyprogesterone
Synonyms
17¦Á-Hydroxy-6¦Á-methylprogesterone ()
17α-Hydroxy-6α-methylprogesterone ()
U8840 ()
MP ()
P&D ID
PD003109
CAS
520-85-4
Tags
available
drug
Drug indication
Solid tumour/cancer
Drug Status
approved
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Medroxyprogesterone (17¦Á-Hydroxy-6¦Á-methylprogesterone) is a synthetic human variant of progesterone that is a progesterone receptor agonist with oral activity. Medroxyprogesterone can induce cell proliferation through the PI3K/Akt signaling pathway. Medroxyprogesterone has an inhibitory effect on atherosclerosis in mice. The progesterone agonist activity of Medroxyprogesterone is less effective than Medroxyprogesterone acetate (HY-B0469)[1][2][3][4].
PRICE
29
DESCRIPTION
The DrugBank entry for medroxyprogesterone shows the structure of the acetate form. Medroxyprogesterone (drug name) is the parent compound with medroxyprogesterone acetate being the active ingredient of the approved drug.
(GtoPdb)
DESCRIPTION
Medroxyprogesterone is a progesterone receptor agonist and a metabolite of medroxyprogesterone 17-acetate.
(Enamine Bioactive Compounds)
DESCRIPTION
Medroxyprogesterone is used in the treatment of renal carcinoma. It is a synthetic progestational hormone used in veterinary practice as an estrus regulator.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
19
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
EUbOPEN Chemogenomics Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
32
Molecular Weight
344.24
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
4
Aromatic Ring Count
0
cLogP
4.08
TPSA
54.37
Fraction CSP3
0.82
Chiral centers
7.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Estrogen/progestogen Receptor
Progesterone Receptor
PGR
Pathway
Endocrinology & Hormones
Vitamin D Related/Nuclear Receptor
Endocrinology/Hormones
Indication
contraceptive
MOA
Progesterone receptor agonist
Therapeutic Class
Contraceptive Agents
Recommended Cell Concentration
1 uM
Source data
