General
Preferred name
MEROPENEM
Synonyms
SM 7338 trihydrate ()
Meropenem Trihydrate ()
MEROPENEM ANHYDROUS ()
(4R,5S,6S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid trihydrate ()
Meropenem (trihydrate) ()
SM 7338 ()
Meropenem (hydrate) ()
Meropenem hydrate ()
Meropenem, anhydrous ()
ICI 194,660 ()
Merrem i.v. ()
Meropenem component of vabomere ()
ICI-194660 ()
Merrem ()
Meronem ()
SM-7338 ()
NSC-759621 ()
Meropenem (as trihydrate) ()
Meropenem trihydrate ()
Meropenem-d6 ()
P&D ID
PD003103
CAS
96036-03-2
119478-56-7
1133424-00-6
Tags
available
covalent binder
drug
Approved by
FDA
First approval
1996
Drug indication
infection
Bacterial infection
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Meropenem trihydrate (SM 7338 trihydrate) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem trihydrate has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL)[1][2].
DESCRIPTION
Meropenem is a parenterally delivered, broad-spectrum carbapenem antibacterial. It is active against Gram-positive and Gram-negative bacteria, and is effective against aerobic and anaerobic pathogens including Klebsiella, E. coli, Enterococcus, Clostridium spp.
(GtoPdb)
DESCRIPTION
Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL)[1][2].
DESCRIPTION
Meropenem is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative bacteria. Meropenem exerts its action by penetrating bacterial cells readily and interfering with the synthesis of vital cell wall components, which leads to cell death.
(Enamine Bioactive Compounds)
DESCRIPTION
Meropenem trihydrate (SM 7338 trihydrate) is a carbapenem antibiotic with broad-spectrum antibacterial activity.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
5
Compound Sets
24
ChEMBL Approved Drugs
ChEMBL Drugs
CovBinderInPDB
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
68
Molecular Weight
383.15
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
0
cLogP
-0.31
TPSA
110.18
Fraction CSP3
0.71
Chiral centers
6.0
Largest ring
5.0
QED
0.56
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
Bacterial
¦Â-Lactamase
Penicillin-binding protein (PBP)
MOA
Antibiotic agonist
bacterial cell wall synthesis inhibitor
Indication
skin infections, intra-abdominal infections, meningitis
Pathway
Microbiology/virology
Anti-infection
Therapeutic Class
Antibiotics
Source data
