General
Preferred name
methazolamide
Synonyms
Acetamide, n-(5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3h)-ylidene)- ()
L584601 ()
CL 8490 ()
P&D ID
PD003099
CAS
554-57-4
Tags
natural product
drug
available
Approved by
FDA
First approval
1959
Drug indication
Glaucoma/ocular hypertension
Drug Status
approved
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Inhibits carbonic anhydrases. This compound is also represented on ChEMBL by the entry with ID CHEMBL19. (GtoPdb)
Compound Sets
16
Concise Guide to Pharmacology 2017/18
6828
Concise Guide to Pharmacology 2019/20
6828
Concise Guide to Pharmacology 2021/22
6828
Drug Repurposing Hub
DrugCentral
1741
DrugCentral Approved Drugs
1741
DrugMAP
DM7J2TA
DrugMAP Approved Drugs
DM7J2TA
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
6828
Ki Database
methazolamide
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
TargetMol Bioactive Compound Library
T0106
External IDs
20
Properties
(calculated by RDKit )
Molecular Weight
236.0
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
-1.42
TPSA
107.41
Fraction CSP3
0.4
Chiral centers
0.0
Largest ring
5.0
QED
0.64
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Target
bCAIV
hCAI
hCAII
CA1, CA12, CA14, CA2, CA4, CA7
Indication
glaucoma, intraocular pressure
MOA
Carbonic anhydrase inhibitor
Source data