General
Preferred name
methylprednisolone
Synonyms
Neo-Medrone ()
Methyl prednisolone acetate ()
Depo-Medrone ()
U 7532 ()
NSC-19987 ()
Methylprednisolone, 6-alpha ()
Methylprednisolone (NSC-19987) ()
NSC-19987,U 7532 ()
U-67,590A ()
J3.872E ()
Medrone ()
Medrol ()
Methylprednisolone ()
Depo-Medrol ()
Medrol Acetate ()
Depmedalone ()
methylprednisolone acetate ()
P&D ID
PD003097
CAS
83-43-2
121673-01-6
6923-42-8
Tags
natural product
drug
available
Approved by
FDA
First approval
1957
Drug Status
approved
vet_approved
Drug indication
Glucocorticoid
Spinal cord injury
Solid tumour/cancer
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Methylprednisolone is a corticosteroid.
Marketed formulations may contain methylprednisolone acetate (PubChem CID 5877).
Methylprednisolone has been reported to activate the TRPC5 ion channel . Methylprednisolone-induced activation of TRPC5 is long lasting, reversible and sensitive to the TRPC5 inhibitor . (GtoPdb)
MOA Unbound glucocorticoids cross cell membranes and bind receptors in the cytoplasm with high affinity. These interactions modify transcription and protein synthesis to inhibit leukocyte infiltration, interfere with inflammatory mediators, and suppress humoral immunity. Suppression of inflammation may be through the action of lipocortins which suppress inflammatory markers.
DESCRIPTION Methylprednisolone is a corticosteroid.
Marketed formulations may contain methylprednisolone acetate (PubChem CID 5877).
DESCRIPTION Glucocorticoid receptor agonist (Tocriscreen Plus)
DESCRIPTION Synthetic progesterone analog (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
29
AdooQ Bioactive Compound Library
A10582
Axon Medchem Screening Library
2066
Cayman Chemical Bioactives
15013
ChEMBL Approved Drugs
CHEMBL650
ChEMBL Drugs
CHEMBL650
Concise Guide to Pharmacology 2017/18
7088
Concise Guide to Pharmacology 2019/20
7088
Concise Guide to Pharmacology 2021/22
7088
Concise Guide to Pharmacology 2023/24
7088
Drug Repurposing Hub
DrugBank
DB00959
DrugBank Approved Drugs
DB00959
DrugCentral
1768
DrugCentral Approved Drugs
1768
DrugMAP
DM4BDON
DrugMAP Approved Drugs
DM4BDON
Guide to Pharmacology
7088
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL650
MedChem Express Bioactive Compound Library
HY-B0260
NCATS Inxight Approved Drugs
X4W7ZR7023
NIH Clinical Collections (NCC)
NPC Screening Collection
NURSA ligand set
nursa/index.jsf?doi=10.1621%2F6A7WO8R4WE
Other bioactive compounds
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
Methylprednisolone
TargetMol Bioactive Compound Library
T1171
Tocris Bioactive Compound Library
4819
Tocriscreen Plus
4819
External IDs
44
Properties
(calculated by RDKit )
Molecular Weight
374.21
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
0
cLogP
1.8
TPSA
94.83
Fraction CSP3
0.73
Chiral centers
8.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Nuclear Receptors
Pathway
Metabolism
Anti-infection
Autophagy
Immunology/Inflammation
Vitamin D Related/Nuclear Receptor
Target
Glucocorticoid Receptor
NR3C1
Glucocorticoid agonist
Bacterial
SARS-CoV
ACE,Apoptosis related,Autophagy,Glucocorticoid Receptor,Immunology & Inflammation related,Interleukins
Primary Target
Glucocorticoid Receptors
MOA
Agonist
Glucocorticoid Receptor agonist
Disease Area
endocrinology, rheumatology, dermatology, infectious disease, allergy, hematology, neurology/psychiatry, gastroenterology
Indication
hypercalcemia, thyroiditis, ankylosing spondylitis, bursitis, osteoarthritis, psoriatic arthritis, seborrheic dermatitis, mycosis, allergic rhinitis, psoriasis, anemia, multiple sclerosis, ulcerative colitis, enteritis
Therapeutic Class
Anticancer Agents
Source data