General
Preferred name
methylprednisolone
Synonyms
Neo-Medrone ()
Methyl prednisolone acetate ()
Depo-Medrone ()
Methylprednisolone, 6-alpha ()
U 7532 ()
NSC-19987,U 7532 ()
Methylprednisolone (NSC-19987) ()
Medrol ()
Medrone ()
NSC-19987 ()
Metilprednisolona ()
6-methylprednisolone ()
Methylprednisolone component of neo-medrol ()
J3.872E ()
U-67,590A ()
6-methyl-prednisolone ()
Methylprednisolone ()
P&D ID
PD003097
CAS
83-43-2
121673-01-6
6923-42-8
Tags
available
drug
Approved by
FDA
First approval
1957
Drug indication
Relapsing-remitting multiple sclerosis
Spinal cord injury
Solid tumour/cancer
Drug Status
vet_approved
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Methylprednisolone is a corticosteroid.
Marketed formulations may contain methylprednisolone acetate (PubChem CID 5877).
Marketed formulations may contain methylprednisolone acetate (PubChem CID 5877).
MOA
Unbound glucocorticoids cross cell membranes and bind receptors in the cytoplasm with high affinity. These interactions modify transcription and protein synthesis to inhibit leukocyte infiltration, interfere with inflammatory mediators, and suppress humoral immunity. Suppression of inflammation may be through the action of lipocortins which suppress inflammatory markers.
DESCRIPTION
Methylprednisolone is a corticosteroid.
Marketed formulations may contain methylprednisolone acetate (PubChem CID 5877).
Methylprednisolone has been reported to activate the TRPC5 ion channel . Methylprednisolone-induced activation of TRPC5 is long lasting, reversible and sensitive to the TRPC5 inhibitor . (GtoPdb)
Marketed formulations may contain methylprednisolone acetate (PubChem CID 5877).
Methylprednisolone has been reported to activate the TRPC5 ion channel . Methylprednisolone-induced activation of TRPC5 is long lasting, reversible and sensitive to the TRPC5 inhibitor . (GtoPdb)
DESCRIPTION
Methylprednisolone (U 7532) is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels[3].
DESCRIPTION
Synthetic progesterone analog
(Tocris Bioactive Compound Library)
DESCRIPTION
Glucocorticoid receptor agonist
(Tocriscreen Plus)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
28
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
NURSA ligand set
Other bioactive compounds
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
47
Molecular Weight
374.21
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
0
cLogP
1.8
TPSA
94.83
Fraction CSP3
0.73
Chiral centers
8.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Nuclear Receptors
Primary Target
Glucocorticoid Receptors
MOA
Agonist
Glucocorticoid Receptor agonist
Disease Area
endocrinology, rheumatology, dermatology, infectious disease, allergy, hematology, neurology/psychiatry, gastroenterology
Indication
hypercalcemia, thyroiditis, ankylosing spondylitis, bursitis, osteoarthritis, psoriatic arthritis, seborrheic dermatitis, mycosis, allergic rhinitis, psoriasis, anemia, multiple sclerosis, ulcerative colitis, enteritis
Target
NR3C1
Glucocorticoid agonist
Autophagy
Bacterial
Glucocorticoid Receptor
SARS-CoV
ACE,Apoptosis related,Autophagy,Glucocorticoid Receptor,Immunology & Inflammation related,Interleukins
Therapeutic Class
Anticancer Agents
Pathway
Anti-infection
Immunology/Inflammation
Vitamin D Related/Nuclear Receptor
Source data
