General
Preferred name
NAFADOTRIDE
Synonyms
P&D ID
PD003083
CAS
149649-22-9
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Nafadotride inhibits potently and stereoselectively [125I]iodosulpride binding at recombinant human dopamine D3 receptors. Ki values are 0.52, 5, and 269 nM for human cloned D3, D2 and D4 receptors respectively.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Highly potent, preferential D3 antagonist
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
10
BOC Sciences Bioactive Compounds
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugMAP
DrugMatrix
Guide to Pharmacology
NIH Clinical Collections (NCC)
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
18
Molecular Weight
365.21
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
2
cLogP
3.71
TPSA
65.36
Fraction CSP3
0.45
Chiral centers
1.0
Largest ring
6.0
QED
0.81
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Source data
